ITGB3, integrin subunit beta 3, 3690

N. diseases: 260; N. variants: 44
Disease: ovarian neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 AlteredExpression disease BEFREE PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via Integrin β3. 31832016 2019
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 Biomarker disease BEFREE Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer. 29021002 2017
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 GeneticVariation disease BEFREE The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers. 19876733 2010
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 AlteredExpression disease LHGDN Integrin alphavbeta3-mediated transcriptional regulation of TIMP-1 in a human ovarian cancer cell line. 18854176 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 GeneticVariation disease LHGDN Thus, it appears that the ITGB3_Leu33Pro polymorphism may potentially increase the risk of ovarian cancer in Polish women with an inherited BRCA1 mutation. 17220212 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 GeneticVariation disease BEFREE Thus, it appears that the ITGB3_Leu33Pro polymorphism may potentially increase the risk of ovarian cancer in Polish women with an inherited BRCA1 mutation. 17220212 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 GeneticVariation disease BEFREE Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer. 16322334 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.060 GeneticVariation disease LHGDN Integrin beta(3) Leu33Pro homozygotes have an increased risk of ovarian cancer. 16322334 2005