JAK3, Janus kinase 3, 3718

N. diseases: 194; N. variants: 28
Disease: Diphtheria ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0012546
Disease: Diphtheria
Diphtheria 		0.010 AlteredExpression disease BEFREE In mice with diphtheria toxin receptor expression in proximal tubules (selective injury model), a relatively selective JAK3 inhibitor, tofacitinib, led to more severe kidney injury, delayed recovery from acute kidney injury, increased inflammatory M1 phenotype markers and decreased reparative M2 phenotype markers of macrophages/dendritic cells, and development of more severe renal fibrosis after diphtheria toxin administration. 27745702 2017