|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results of this study suggested that Apa/p NPs could inhibit the growth of melanoma tumors by inhibiting the phosphorylation and expression of VEGFR-2 and downstream ERK1/2, providing a theoretical basis for the clinical application of Apatinib in the treatment of melanoma.
|
31668370 |
2020 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that reduced expression of NLK in melanoma correlates with VEGFR2-related microvessel formation and melanoma metastasis.
|
30778016 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Downstream of VEGFR, trametinib is an FDA-approved MEK inhibitor used for melanoma.
|
28377484 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a Novel Pathogenic Germline KDR Variant in Melanoma.
|
26631613 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, the results demonstrate that NRP-1 is involved in melanoma progression through VEGFR-2-dependent and -independent mechanisms and suggest NRP-1 as a target for the treatment of the metastatic disease.
|
23685409 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The knockdown of VEGFR1 in three melanoma cell lines completely disrupts Matrigel-induced CLS formation, whereas inhibition of VEGFR2 kinase with a specific inhibitor, protein tyrosine kinase inhibitor II (PTKi-II), does not affect the process, indicating that VEGFR2 signaling is not involved in VEGFA-mediated melanoma VM.
|
21389833 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed a significant decrease in microvascular density (MVD) in response to low dose metronomic cyclophosphamide chemotherapy in both malignant melanoma (with higher proportion VEGFR2 positive blood vessels; 93%) and colorectal carcinoma (with lower proportion VEGFR2 positive blood vessels; 60%) xenografts.
|
21159176 |
2010 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analyzing the contribution of progenitor-like cells during melanoma metastasis formation, we observed an enhanced proliferation and mobilization of VEGFR-1+ myeloid and VEGFR-2+ endothelial cells with progenitor potential by the induction of melanoma lung metastasis, which was not influenced by interference with VEGFR signaling.
|
17230507 |
2007 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
VEGF and VEGFR-2 immunohistochemistry in human melanocytic naevi and cutaneous melanomas.
|
15714119 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
In addition, VEGF receptors (VEGFR)1, VEGFR2 and neurophilin-1 are expressed in A375 melanoma cells.
|
15610528 |
2004 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased expression of VEGF-receptors (FLT-1, KDR, NRP-1) and thrombospondin-1 is associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype, in malignant melanoma.
|
15166498 |
2003 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Increased expression of VEGF-receptors (FLT-1, KDR, NRP-1) and thrombospondin-1 is associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype, in malignant melanoma.
|
15166498 |
2003 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A combination of plasmid DNAs encoding murine fetal liver kinase 1 extracellular domain, murine interleukin-12, and murine interferon-gamma inducible protein-10 leads to tumor regression and survival in melanoma-bearing mice.
|
12684754 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas.
|
11438469 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using reverse-transcriptase polymerase chain reaction (RT-PCR), the expression of VEGF was found in 15/15 human tumour cell lines examined, while the VEGF receptor KDR was detected only in three melanoma cell lines (MeWo and A375, both wild type and metastatic variant).
|
8554590 |
1995 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Relatively abundant levels of UFO/AXL and KDR mRNAs were observed in a subset of the melanoma cell lines whereas most of the remaining protein kinases were expressed at similar levels in both normal and transformed melanocytes.
|
7858416 |
1994 |