|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of KISS1 gene expression promotes progression of breast cancer and melanoma, resulting in the development of distant metastases.
|
29269086 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines.
|
25810563 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KiSS-1 has been identified as a putative metastasis-suppressor gene in human melanomas and breast cancer cell lines.
|
19645016 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In this work, we used suppression subtractive hybridization (SSH) to investigate the molecular signature of melanoma progression, by comparing a group of metastatic cell lines with an RGP-like cell line showing characteristics of early neoplastic lesions including expression of the metastasis suppressor KISS1, lack of alphavbeta3-integrin and low levels of RHOC.
|
18211678 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, levels of the secreted metastasis-suppressor KiSS1 (melanoma metastasis suppressor) were increased in the secreted proteome of the MRJ(L)-expressing cells.
|
18328103 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Kisspeptin (KiSS-1) gene, initially described as a melanoma metastasis suppressor gene, encodes a number of peptides (kp-54, kp-14, kp-13, kp-10), which are endogenous ligands to a G protein-coupled receptor, referred as hOT7T175 or AXOR12 or GPR54.
|
18583061 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KiSS1 is a putative metastasis suppressor gene in melanoma and breast cancer-encoding kisspeptins, which are also described as neuroendocrine regulators of the gonadotropic axis.
|
17914099 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KiSS-1 has been identified as a putative human metastasis suppressor gene in melanomas and in breast cancer cell lines.
|
16320113 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KiSS1 has been identified as a metastasis suppressor gene in melanoma and breast carcinomas.
|
16283480 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The KISS1 metastasis suppressor gene inhibits metastasis in both in vivo melanoma and breast carcinoma models.
|
12650602 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KISS1 metastasis suppressor gene inhibits metastasis in both in vivo melanoma and breast carcinoma models.
|
12650602 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we implicated a specific gene on chromosome 6 in the etiology of melanoma metastasis and identified potential up-stream regulators of KISS1 and TXNIP.
|
12543799 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Metastin inhibits chemotaxis and invasion of hOT7T175-transfected CHO cells in vitro and attenuates pulmonary metastasis of hOT7T175-transfected B16-BL6 melanomas in vivo.
|
11385580 |
2001 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The findings in this study show, for the first time, KiSS1 down-regulation during the progression of melanoma in vivo and strongly suggest that inactivation of a tumor suppressor gene(s) mapping to 6q16.3-q23 by deletion or mutation coupled with LOH may lead to the down-regulation of KiSS1.
|
11606374 |
2001 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, a basal level mRNA expression of KISS1, described as metastasis suppressor in melanoma and breast, was observed in both the lines and had slightly higher expression in T24T.
|
11592309 |
2000 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to its already described role in melanoma, our results show that KiSS-1 also functions as a metastasis suppressor gene in at least some human breast cancers.
|
9192814 |
1997 |