Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CTD_human |
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.
|
27793025 |
2016 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
KIT mutations, compared with PDGFRA mutations and wild type, represent a poorer prognostic marker in high risk or malignant GISTs.
|
24674052 |
2014 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
SomaticCausalMutation
|
disease |
ORPHANET |
Succinate dehydrogenase deficiency in pediatric and adult gastrointestinal stromal tumors.
|
23730622 |
2013 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CTD_human |
Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells.
|
20028860 |
2010 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Tumors with deletion/insertion mutations affecting codons 557/558 of the KIT gene seem to represent a distinct subset of malignant GISTs.
|
18350628 |
2008 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Rectal gastrointestinal stromal tumors associated with a novel germline KIT mutation.
|
18183595 |
2008 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
A mouse model of a human multiple GIST family with KIT-Asp820Tyr mutation generated by a knock-in strategy.
|
18098338 |
2008 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Familial gastrointestinal stromal tumors caused by the novel KIT exon 17 germline mutation N822Y.
|
18724244 |
2008 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Imatinib in the management of multiple gastrointestinal stromal tumors associated with a germline KIT K642E mutation.
|
17824795 |
2007 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CTD_human |
Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.
|
16740725 |
2006 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis.
|
16143141 |
2005 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.
|
16061643 |
2005 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
C-kit gene mutations occur preferentially in malignant GISTs and might be a clinically useful adjunct marker in the evaluation of GISTs and can help to differentiate GISTs from other mesenchymal tumors of gastrointestinal tract, such as smooth muscle tumors, schwannomas, etc.
|
15112348 |
2004 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia.
|
14977822 |
2004 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase.
|
12754375 |
2003 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Mutations of KIT are common in malignant GISTs and lead to constitutional activation of tyrosine kinase function, which causes cellular proliferation and resistance to apoptosis.
|
14515284 |
2003 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.
|
11984533 |
2002 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Several reports have suggested that KIT gene mutations are more common in malignant GISTs than in benign lesions, and it has been proposed that mutations in exon 11 of KIT are a negative prognostic factor.
|
12000708 |
2002 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene.
|
11208730 |
2001 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa.
|
11505412 |
2001 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
KIT mutations were seen in four of five malignant GISTs with loss of chromosome 9, but only in one of four malignant tumors with loss of chromosome 1.
|
11454425 |
2001 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GeneticVariation
|
disease |
BEFREE |
Mutation in the c-kit gene is associated with aggressive features and poor prognosis, and malignant GISTs frequently have mutations in the c-kit gene.
|
11005253 |
2000 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
GermlineCausalMutation
|
disease |
ORPHANET |
Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors.
|
11073817 |
2000 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors.
|
11073817 |
2000 |
Gastrointestinal Stromal Sarcoma
|
0.670 |
Biomarker
|
disease |
CLINGEN |
Familial gastrointestinal stromal tumours with germline mutation of the KIT gene.
|
9697690 |
1998 |