|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Variants of WNK1 (lysine deficient protein kinase 1), ADRB2 (β2 adrenergic receptor), NEDD4L (ubiquitin-protein ligase NEDD4-like), KLK1 (kallikrein 1) contribute to hypertension, and AKR1C3 (aldo-keto reductase family1 member C3), is associated with preeclampsia.
|
29777907 |
2018 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Previous reports have shown that polymorphism of the human tissue kallikrein 1 (KLK1) A1789G gene is associated with susceptibility to hypertension.
|
23765970 |
2013 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Tissue kallikrein, blood pressure regulation, and hypertension: insight from genetic kallikrein deficiency.
|
23324381 |
2013 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
rAAV-mediated HK gene delivery has multiple therapeutic possibilities for treating hypertension, not only by decreasing blood pressure, but also by directly inhibiting end-organ damage.
|
19684610 |
2009 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Our study indicates that rAAV-mediated human tissue kallikrein gene delivery is a potentially safe method for the long-term treatment of hypertension.
|
18565278 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
A coding polymorphism of the kallikrein 1 gene is associated with essential hypertension: a tagging SNP-based association study in a Chinese Han population.
|
17762646 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Relationship between the regulatory region polymorphism of human tissue kallikrein gene and essential hypertension.
|
15905889 |
2005 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The levels of tissue kallikrein are reduced in humans and animal models with hypertension, cardiovascular and renal disease.
|
15653716 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Because the kallikrein-kinin system has been shown to be involved in renal function, including salt homeostasis, it is likely that the reduced expression of Klk1 contributes to salt-sensitive hypertension in Dahl salt-sensitive rats.
|
15809361 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These data suggest that both hKLK1 gene delivery and recombinant enzyme administration can be used as alternative strategies for treating human hypertension.
|
15031667 |
2004 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
These results suggest that gene therapy with human tissue kallikrein may have potential as a treatment for hypertension and associated insulin resistance.
|
14568997 |
2003 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results suggest that gene therapy with human tissue kallikrein may have potential as a treatment for hypertension and associated insulin resistance.
|
14568997 |
2003 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
The observed genetic association suggests an etiologic effect of the KLK1 promoter on hypertension and/or hypertension associated ESRD.
|
11849458 |
2002 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The observed genetic association suggests an etiologic effect of the KLK1 promoter on hypertension and/or hypertension associated ESRD.
|
11849458 |
2002 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings showed that the expression of human tissue kallikrein via gene delivery has protective effects against hypertension and renal injury in DOCA-salt hypertensive rats.
|
10604525 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The tissue kallikrein-kinin system has been documented to be involved in the pathogenesis of hypertension and renal diseases.
|
9458239 |
1998 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Application of adenovirus-mediated systemic expression of the tissue kallikrein gene may provide a unique way of delivering the gene product into the vasculature and could have important therapeutic implications in treating hypertension.
|
9358025 |
1997 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The tissue kallikrein-kinin system has been postulated to play a role in blood pressure homeostasis and the pathogenesis of clinical hypertension.
|
9228551 |
1997 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To demonstrate potential therapeutic effects of human tissue kallikrein in hypertension, spontaneously hypertensive rats were subjected to somatic gene therapy.
|
7535795 |
1995 |
|
Kallikrein, Decreased Urinary Activity of
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Kallikrein, Decreased Urinary Activity of
|
0.400 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Myocardial Infarction
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our results indicate that TK-modified MSCs provide enhanced protection against cardiac injury, apoptosis and inflammation, and promote neovascularization after MI, leading to cardiac function improvement.
|
23697984 |
2013 |
|
Myocardial Infarction
|
0.350 |
Biomarker
|
disease |
BEFREE |
Using an MI mouse model, we then examined the in vivo effects of human TK gene adenoviral vector (Ad.hTK) administration on the number of CD34(+)Flk-1(+) progenitors in the peripheral circulation, heart tissue, extent of vasculogenesis, and heart function.
|
22435954 |
2012 |
|
Myocardial Infarction
|
0.350 |
Biomarker
|
disease |
BEFREE |
These data provide the first direct evidence that tissue kallikrein protects against acute-phase MI by promoting neovascularization, restoring regional blood flow and improving cardiac function through the kinin B2 receptor-Akt-GSK-3beta and VEGF signalling pathways.
|
18689794 |
2008 |
|
Myocardial Infarction
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
A chronically activated transgenic kallikrein kinin system with expression of human kallikrein-1 gene counteracts the progression of left ventricular contractile dysfunction after experimental myocardial infarction.
|
17022964 |
2006 |