KLK1, kallikrein 1, 3816

N. diseases: 132; N. variants: 3
Disease: Kidney Failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.030 AlteredExpression disease BEFREE Levels of tissue kallikrein (TK) are significantly lower in the urine of patients with kidney failure, and TK expression is specifically diminished in rat kidney after recovery from ischemia-reperfusion injury. 20089675 2010
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.030 GeneticVariation disease BEFREE The -130 G12 allele in the KLK1 promoter was associated with lower transcriptional activity and hypertensive end-stage renal disease (ESRD) in blacks. 15086490 2004
CUI: C0035078
Disease: Kidney Failure
Kidney Failure 		0.030 GeneticVariation disease BEFREE Association of the tissue kallikrein gene promoter with ESRD and hypertension. 11849458 2002