|
Osteitis Deformans
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining and pathological studies were performed on tumor samples, and diagnosis of PD of the nipple was confirmed by expression of proteins characteristic of Paget cells (epidermal growth factor 2 (HER2), androgen receptor (AR), cytokeratin 7 (CK7), cytokeratin 8/18 (CK8/18), and mucin 1 (MUC1)).
|
31720992 |
2020 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Keratin 8/18 (K8/18) are the exclusively expressed keratins intermediate filaments pair in hepatocytes that protect against liver injuries and viral infection.
|
31515557 |
2020 |
|
Hepatitis B, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Keratin 8 mutations were associated with susceptibility to chronic hepatitis B and related progression.
|
31515557 |
2020 |
|
Paget Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining and pathological studies were performed on tumor samples, and diagnosis of PD of the nipple was confirmed by expression of proteins characteristic of Paget cells (epidermal growth factor 2 (HER2), androgen receptor (AR), cytokeratin 7 (CK7), cytokeratin 8/18 (CK8/18), and mucin 1 (MUC1)).
|
31720992 |
2020 |
|
Merkel cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
By contrast, cytokeratin 8, 18 and 20 and a CD99 with a dot pattern as well as high EMA expression were identified as characteristic features of virus-positive Merkel cell carcinoma.
|
31201352 |
2019 |
|
Chordoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study represents the first systematic investigation into the role of KRT8 in chemoresistance of chordoma and our results highlight a possible strategy of targeting KRT8 to overcome chordoma chemoresistance.
|
31767864 |
2019 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Keratin 8 is a potential self-antigen in the coronary artery disease immunopeptidome: A translational approach.
|
30811493 |
2019 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Keratin 8 is a potential self-antigen in the coronary artery disease immunopeptidome: A translational approach.
|
30811493 |
2019 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Keratin 8 was selected for further study in patient PBMCs which elicited T Effector cell responses in CAD patients compared to controls, associated with reduced PD-1 mRNA expression.
|
30811493 |
2019 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, the hepatic lipid profile in Krt18<sup>-/-</sup> mice, which accumulate KRT8, closely resembles human SH lipid profiles and shows that the excess of KRT8 over KRT18 determines the likelihood to develop SH-associated HCC linked with enhanced lipogenesis.
|
30439626 |
2019 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes.
|
29719117 |
2018 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes.
|
29719117 |
2018 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Immunofluorescence analyses showed that thymic lymphomas presented epithelial areas characterized by keratin (Krt) 5 and Krt8 expression, adjacently to epithelial-free areas negative for Krt expression.
|
30256907 |
2018 |
|
Anaplastic thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we provide evidence that KRT8 plays a direct role in the growth of ATCs.
|
29443941 |
2018 |
|
Disseminated Malignant Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The perinuclear reorganization of keratin 8 (K8) is an important biochemical phenomenon reflecting changes in the physical properties of metastatic cancer.
|
29796162 |
2018 |
|
insulinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mitochondria in K8 wild-type β cells and MIN6 insulinoma cells overexpressing K8 and 18 are more stationary compared with mitochondria in keratin-deficient cells.
|
28666985 |
2017 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, regulated enhancement of autophagy with concurrent increased expression of KRT8 and the inhibition of KRT8 phosphorylation serve to inhibit oxidative stress-induced EMT of RPE cells as well as to prevent cell death, suggesting that pharmacological manipulation of KRT8 upregulation through autophagy with combined inhibition of the MAPK1/3 pathway may be attractive therapeutic strategies for the treatment of AMD.
|
28045574 |
2017 |
|
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The mechanism of its antitumor effect involved in (a) reducing oxidative stress injury through up-regulating activities of CAT and SOD; (b) down-regulating the levels of inflammatory factors, like TNF-α, IL6, COX-2, and PGE2; (c) activation of caspase-3 and up-regulating the pro-apoptotic protein Bax; (d) decreasing the expression of PCNA; (e) depressing the expression of cancer stem cells marker CD133; (f) suppressing aberrant expression of cytokeratin 8 and 18; and (g) inhibiting EGFR/ PI3 K/Akt, EGFR/Ras/Erk and NF-κB pathways.
|
27991692 |
2017 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of keratin 8/18 variants with non-alcoholic fatty liver disease and insulin resistance in Chinese patients: A case-control study.
|
28652657 |
2017 |
|
Squamous cell carcinoma of skin
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways regulated by site-specific phosphorylation of Keratin-8 in skin squamous cell carcinoma derived cell line.
|
28176443 |
2017 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Kaplan-Meier analysis proved that KRT8 was associated with overall survival of patients with GC that patients with high KRT8 expression tend to have unfavorable outcome.
|
27865045 |
2017 |
|
Osteopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic deletion of keratin 8 corrects the altered bone formation and osteopenia in a mouse model of cystic fibrosis.
|
26769674 |
2016 |
|
Tracheal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In mice, activated basal cells (p63+, KRT14+, KRT8+) initiate injury repair to the trachea, whereas club cells coordinate distal airway repair.
|
27343193 |
2016 |
|
Abnormal bone formation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Collectively, the results show that genetic or pharmacologic targeting of Krt8 leads to correction of osteoblast dysfunctions, altered bone formation and osteopenia in F508del-Cftr mice, providing a therapeutic strategy targeting the Krt8-F508del-CFTR interaction to correct the abnormal bone formation and bone loss in cystic fibrosis.
|
26769674 |
2016 |
|
Anaplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we show that expression of PIK3CA(H1047R) in lineage-committed basal Lgr5-positive and luminal keratin-8-positive cells of the adult mouse mammary gland evokes cell dedifferentiation into a multipotent stem-like state, suggesting this to be a mechanism involved in the formation of heterogeneous, multi-lineage mammary tumours.
|
26266975 |
2015 |