|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the tested red clover extract and genistein induced keratin-8 (luminal and prognostic marker in breast cancer) expression only in MCF-7 cells, but this effect was not seen following treatment with the soybean extract.
|
31171079 |
2019 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apart from the 2 well-known genes EPCAM and MELK, during the development of BC, KRT8, KRT19, KPNA2, and ECT2 also play key roles, and may be used as new targets for the detection or treatment of BC.In summary, our study demonstrated that hub genes such as EPCAM and MELK are highly correlated with breast cancer development.
|
30732163 |
2019 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Serial whole tissue sections of 154 consecutive invasive breast carcinomas were stained for Ki67 and cytokeratin 8/18 with immunohistochemistry in a clinical setting.
|
29349710 |
2018 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis.
|
29796187 |
2018 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Two different methods were used to label breast cancer tissues for BRCA1: (1) Dual immunofluoresent staining with BRCA1 and cytokeratin 8/18 and (2) immunohistochemical staining using the previously validated MS110 mouse monoclonal antibody.
|
28863181 |
2017 |
|
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
|
27197191 |
2016 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Identification of a mimotope for circulating anti-cytokeratin 8/18 antibody and its usage for the diagnosis of breast cancer.
|
23128437 |
2013 |
|
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant.
|
20061804 |
2010 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of SMAR1 and Cytokeratin 8 proteins in different grades of cancer using tissue microarray point out at the inverse expression profiles of these genes (i.e. low levels of SMAR1 correlating with high expression of Cytokeratin 8) in higher grades of breast cancer.
|
18822384 |
2009 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In this report, we observed elevated expression of cytokeratin 8 (CK8) in MCF-7/MX, a mitoxantrone (MX)-selected human breast tumor cell line with the MDR phenotype known as overexpression of breast cancer resistant protein (BCRP).
|
18725232 |
2008 |
|
Cirrhosis, Familial
|
0.500 |
GeneticVariation
|
disease |
UNIPROT |
Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.
|
12724528 |
2003 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A human breast cancer cell line (MCF7S) and its multidrug resistant (MDR) subline (MCF7R) were characterized here for their intermediate filaments (IFs) expression (cytokeratin 8, 18, 19 and vimentin) as a function of their resistance phenotype.
|
9413178 |
1998 |
|
Breast Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A cytokeratin 8-like protein with plasminogen-binding activity is present on the external surfaces of hepatocytes, HepG2 cells and breast carcinoma cell lines.
|
7542667 |
1995 |
|
Cirrhosis, Familial
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Apart from the 2 well-known genes EPCAM and MELK, during the development of BC, KRT8, KRT19, KPNA2, and ECT2 also play key roles, and may be used as new targets for the detection or treatment of BC.In summary, our study demonstrated that hub genes such as EPCAM and MELK are highly correlated with breast cancer development.
|
30732163 |
2019 |
|
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the tested red clover extract and genistein induced keratin-8 (luminal and prognostic marker in breast cancer) expression only in MCF-7 cells, but this effect was not seen following treatment with the soybean extract.
|
31171079 |
2019 |
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis.
|
29796187 |
2018 |
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Two different methods were used to label breast cancer tissues for BRCA1: (1) Dual immunofluoresent staining with BRCA1 and cytokeratin 8/18 and (2) immunohistochemical staining using the previously validated MS110 mouse monoclonal antibody.
|
28863181 |
2017 |
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
BEFREE |
Identification of a mimotope for circulating anti-cytokeratin 8/18 antibody and its usage for the diagnosis of breast cancer.
|
23128437 |
2013 |
|
Malignant neoplasm of breast
|
0.380 |
Biomarker
|
disease |
CTD_human |
Estrogen receptor-alpha-interacting cytokeratins potentiate the antiestrogenic activity of fulvestrant.
|
20061804 |
2010 |
|
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of SMAR1 and Cytokeratin 8 proteins in different grades of cancer using tissue microarray point out at the inverse expression profiles of these genes (i.e. low levels of SMAR1 correlating with high expression of Cytokeratin 8) in higher grades of breast cancer.
|
18822384 |
2009 |
|
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
In this report, we observed elevated expression of cytokeratin 8 (CK8) in MCF-7/MX, a mitoxantrone (MX)-selected human breast tumor cell line with the MDR phenotype known as overexpression of breast cancer resistant protein (BCRP).
|
18725232 |
2008 |
|
Malignant neoplasm of breast
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
A human breast cancer cell line (MCF7S) and its multidrug resistant (MDR) subline (MCF7R) were characterized here for their intermediate filaments (IFs) expression (cytokeratin 8, 18, 19 and vimentin) as a function of their resistance phenotype.
|
9413178 |
1998 |
|
Liver Cirrhosis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Keratin 8 variants are infrequent in patients with alcohol-related liver cirrhosis and do not associate with development of hepatocellular carcinoma.
|
23078008 |
2012 |
|
Liver Cirrhosis
|
0.340 |
Therapeutic
|
disease |
CTD_human |
Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.
|
20538000 |
2010 |