KRT8, keratin 8, 3856

N. diseases: 166; N. variants: 16
Disease: Abnormal bone formation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0231557
Disease: Abnormal bone formation
Abnormal bone formation 		0.010 GeneticVariation disease BEFREE Collectively, the results show that genetic or pharmacologic targeting of Krt8 leads to correction of osteoblast dysfunctions, altered bone formation and osteopenia in F508del-Cftr mice, providing a therapeutic strategy targeting the Krt8-F508del-CFTR interaction to correct the abnormal bone formation and bone loss in cystic fibrosis. 26769674 2016