|
Kidney Failure, Chronic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of Chronic Kidney Disease Stages Across Ancestries: The PAGE Study.
|
31178898 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The results showed that the expression levels of lnc-ATB (p < 0.001) and CCAT1 (p = 0.024), but not OCC-1 (p = 0.24), were significantly upregulated in the CRC compared with the healthy group.
|
31093977 |
2019 |
|
Colorectal Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here, we revealed that OCC-1 plays a tumor suppressive role in CRC.
|
29931370 |
2018 |
|
Colorectal Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
OCC-1 and APPL2 neighboring genes located in 12q.23.3 human chromosome region are related to colorectal cancer.
|
30218350 |
2018 |
|
Colorectal Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of the known OCC-1 variant (assigned as OCC-1A/B) was limited to CRC, and its overexpression increased survival of CRC-originated SW480 cells (Wnt<sup>+</sup>), while resulting in apoptosis of Wnt-suppressed SW480 cells or HeLa cells (Wnt<sup>-</sup>) detected by PI staining.
|
27986894 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we revealed that OCC-1 plays a tumor suppressive role in CRC.
|
29931370 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
OCC1-SEAP cells were injected s.c. or intraperitoneally into nude mice and tumor volume was measured as well as plasma SEAP levels as the tumors developed.
|
11862422 |
2002 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Histological evaluation of xenografts from OCC1 in the 33th passage implanted and grown in nude (athymic) mice revealed a morphology identical to that of the original tumor.
|
2354825 |
1990 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
|
29931370 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
OCC-1 and APPL2 neighboring genes located in 12q.23.3 human chromosome region are related to colorectal cancer.
|
30218350 |
2018 |
|
ovarian neoplasm
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, using pair-matched wild-type p53 CDDP-sensitive (OV2008) and -resistant (C13*) cells, and p53-compromised CDDP-resistant cells (A2780cp, OCC-1, OVCAR-3 and SKOV3), we have demonstrated (i) the existence of site-specific differences in phospho-Ser-Chk1 content between sensitive and resistant cells in response to CDDP; (ii) PPM1D, but not phosphoinositide-3-kinase-related kinase Ataxia Telangiectasia and Rad3 related protein (ATR), is important in the regulation of CDDP-induced Chk1 activation and OVCA cell chemosensitivity; (iii) PPM1D downregulation sensitizes resistant cells to CDDP primarily by activating Chk1 and p53.
|
21927021 |
2012 |
|
Malignant neoplasm of ovary
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, using pair-matched wild-type p53 CDDP-sensitive (OV2008) and -resistant (C13*) cells, and p53-compromised CDDP-resistant cells (A2780cp, OCC-1, OVCAR-3 and SKOV3), we have demonstrated (i) the existence of site-specific differences in phospho-Ser-Chk1 content between sensitive and resistant cells in response to CDDP; (ii) PPM1D, but not phosphoinositide-3-kinase-related kinase Ataxia Telangiectasia and Rad3 related protein (ATR), is important in the regulation of CDDP-induced Chk1 activation and OVCA cell chemosensitivity; (iii) PPM1D downregulation sensitizes resistant cells to CDDP primarily by activating Chk1 and p53.
|
21927021 |
2012 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, using pair-matched wild-type p53 CDDP-sensitive (OV2008) and -resistant (C13*) cells, and p53-compromised CDDP-resistant cells (A2780cp, OCC-1, OVCAR-3 and SKOV3), we have demonstrated (i) the existence of site-specific differences in phospho-Ser-Chk1 content between sensitive and resistant cells in response to CDDP; (ii) PPM1D, but not phosphoinositide-3-kinase-related kinase Ataxia Telangiectasia and Rad3 related protein (ATR), is important in the regulation of CDDP-induced Chk1 activation and OVCA cell chemosensitivity; (iii) PPM1D downregulation sensitizes resistant cells to CDDP primarily by activating Chk1 and p53.
|
21927021 |
2012 |
|
ovarian neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we examined PC expression in six normal ovarian surface epithelium (OSE) cultures, nine primary ovarian cancer (OC) cultures, and three established OC cell lines (Hey, HeyC2, and OCC-1).
|
12805404 |
2003 |
|
Malignant neoplasm of ovary
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we examined PC expression in six normal ovarian surface epithelium (OSE) cultures, nine primary ovarian cancer (OC) cultures, and three established OC cell lines (Hey, HeyC2, and OCC-1).
|
12805404 |
2003 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this study, we examined PC expression in six normal ovarian surface epithelium (OSE) cultures, nine primary ovarian cancer (OC) cultures, and three established OC cell lines (Hey, HeyC2, and OCC-1).
|
12805404 |
2003 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Assessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCR.
|
31006040 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Assessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCR.
|
31006040 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Assessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCR.
|
31006040 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Assessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCR.
|
31006040 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, a negative correlation of expression is evident between APPL2 and OCC-1 genes in breast cancer specimen.
|
30218350 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, a negative correlation of expression is evident between APPL2 and OCC-1 genes in breast cancer specimen.
|
30218350 |
2018 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OCC-1 was initially reported as an up-regulated gene in colon carcinoma, without knowing its mechanism of action.
|
27986894 |
2017 |
|
Ataxia Telangiectasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, using pair-matched wild-type p53 CDDP-sensitive (OV2008) and -resistant (C13*) cells, and p53-compromised CDDP-resistant cells (A2780cp, OCC-1, OVCAR-3 and SKOV3), we have demonstrated (i) the existence of site-specific differences in phospho-Ser-Chk1 content between sensitive and resistant cells in response to CDDP; (ii) PPM1D, but not phosphoinositide-3-kinase-related kinase Ataxia Telangiectasia and Rad3 related protein (ATR), is important in the regulation of CDDP-induced Chk1 activation and OVCA cell chemosensitivity; (iii) PPM1D downregulation sensitizes resistant cells to CDDP primarily by activating Chk1 and p53.
|
21927021 |
2012 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of OCC-1 mRNA were observed in three of eight colon carcinomas as compared to normal mucosa of the same patient.
|
11890990 |
2002 |