LDHA, lactate dehydrogenase A, 3939

N. diseases: 185; N. variants: 0
Disease: Renal Cell Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.030 AlteredExpression disease BEFREE Orthotopic tumors were created in mice using human renal cell carcinoma (RCC) lines (A498, 786-O, UOK262) with varying expression of lactate dehydrogenase A (<i>LDHA</i>) which catalyzes the pyruvate-to-lactate conversion, and varying expression of monocarboxylate transporter 4 (<i>MCT4</i>) which mediates lactate export out of the cells. 30189677 2018
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.030 AlteredExpression disease BEFREE LDHA was overexpressed in RCC tissues and predicted a worse survival following renal resection. 28983605 2017
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.030 Biomarker disease BEFREE These findings are consistent with the view that LDHA, as an oncogene, might be a potential therapeutic target in RCC. 27027898 2017