LDHA, lactate dehydrogenase A, 3939

N. diseases: 185; N. variants: 0
Disease: Immunosuppression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4048329
Disease: Immunosuppression
Immunosuppression 		0.010 AlteredExpression disease BEFREE Our results suggest that expressions of LDH-A and lactate by macrophage in the tumor microenvironment are major drivers of T-cell immunosuppression, strongly supporting the concept of targeting stromal LDH-A as an effective strategy to blunt tumoral immune escape.<i></i>. 28446465 2017