LDLR, low density lipoprotein receptor, 3949

N. diseases: 336; N. variants: 1434
Disease: Atherosclerotic lesion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE In low-density lipoprotein receptor-deficient mice, Dll4 antibody abolished atherosclerotic lesion development accelerated in Ldlr-/- mice. 30586693 2019
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Deficiency of adipocyte IKK β did not affect atherosclerotic lesion sizes but resulted in enhanced lesional inflammation and increased plaque vulnerability in obese IKK β<sup>ΔAd</sup> LDLR <sup>-/-</sup> mice. 31203708 2019
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 GeneticVariation disease BEFREE Combined, these pro- and anti-atherogenic effects did not translate into a significant difference in atherosclerotic lesion formation upon bone marrow-specific deletion of Prg4 in low-density lipoprotein receptor KO mice. 29772480 2018
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE However, deficiency of β-catenin significantly increased atherosclerotic lesion areas in the aortic root of LDLR<sup>-/-</sup> (low-density lipoprotein receptor-deficient) mice without affecting the plasma lipid levels and atherosclerotic plaque composition. 29724817 2018
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE No difference in atherosclerotic lesion size was found in <i>Ldlr</i><sup>-/-</sup> (low-density lipoprotein receptor null) mice transplanted with bone marrow (BM) cells from <i>Ncr1</i><sup> 29046274 2018
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 GeneticVariation disease BEFREE We examined the effects of Ldlr deletion on lipoprotein metabolism and atherosclerotic lesion formation in Sprague-Dawley rats. 28469073 2017
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE We demonstrate that deficiency in Batf3 entailed mild effects on the immune response in the spleen but did not alter atherosclerotic lesion formation in the aorta or aortic root, nor affected plaque phenotype in low density lipoprotein receptor-deficient mice fed a high fat diet. 28771609 2017
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Bilirubin Prevents Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor-Deficient Mice by Inhibiting Endothelial VCAM-1 and ICAM-1 Signaling. 28365565 2017
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. 28225891 2017
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 AlteredExpression disease BEFREE We observed that Ogg1 expression decreases over time in atherosclerotic lesion macrophages of low-density lipoprotein receptor (Ldlr) knockout mice fed a Western diet. 27384322 2016
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Here, we utilized pcsk9(-/-) mice and an anti-PCSK9 antibody to study the role of the LDL receptor (LDLR) and ApoE in PCSK9-mediated regulation of plasma cholesterol and atherosclerotic lesion development. 25258384 2014
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Absence of sortilin in gene-targeted mice reduces secretion of lipoproteins from the liver and ameliorates hypercholesterolemia and atherosclerotic lesion formation in LDL receptor-deficient animals. 20816088 2010
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE We crossbred CRP transgenic animals expressing the human CRP pentraxin (huCRP) to LDLR(-/-) mice, fed the resulting double mutants a pro-atherogenic Western type diet (WTD) for four, eight or 12 weeks, respectively, and quantitated atherosclerotic lesion development. 18217154 2008
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Increased expression of glutathione reductase in macrophages decreases atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. 17363688 2007
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE More recently, a direct role for UCP-2 in the regulation of atherogenesis has been suggested by the observation that bone marrow transplantation from UCP-2-deficient mice to low-density lipoprotein receptor-deficient mice markedly increased atherosclerotic lesion size. 17462780 2007
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice. 17293475 2007
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. 17478758 2007
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. 16456089 2006
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Atherosclerotic lesion size in LDL receptor-deficient mice is reduced as a consequence of the increase in natural antibody titers, and IL-5 is identified as the link between the adaptive and natural immune systems. 15286796 2004
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE We now report that in comparison to LacZ transfected control mice gene transfer with sMSR adenoviruses via tail vein injection (1 x 10(9) pfu) reduces atherosclerotic lesion area in hypercholesterolemic LDL receptor knock-out mice by 14 (P<0.05) and 19% (P=0.01), 4 and 6 weeks after the gene transfer. 12860255 2003
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 AlteredExpression disease BEFREE Reduced connexin43 expression inhibits atherosclerotic lesion formation in low-density lipoprotein receptor-deficient mice. 12600918 2003
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice. 14664792 2003
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.100 Biomarker disease BEFREE The presence or absence of the LDLR in the transplanted bone marrow did not influence these results.In conclusion, introduction of MSR1-overexpressing bone marrow in LDLR(-/-) mice via bone marrow transplantation resulted in a slight increase in lipoprotein levels, but had no effect on the atherosclerotic lesion area, despite increased scavenger receptor activity in vitro. 10974047 2000