|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity is strongly associated with leptin resistance.
|
29789721 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obese AR mice models were established to verify the effect of obesity on leptin and OPN as well T<sub>H</sub> regulation.
|
29885866 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with increased blood concentrations of the anorexigenic hormone leptin; however, obese individuals are resistant to its anorexigenic effects.
|
30135249 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obese animals treated with TTI presented lower plasma leptin than the non-treated obese animals.
|
30537704 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with oxidative stress, a major factor in carcinogenesis, and with high leptin concentration.
|
30563501 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity-induced 'selective sensitization' of the brain to the sympathoexcitatory effects of insulin and leptin may contribute to elevated basal SNA, and therefore hypertension development, in males with obesity.
|
30628058 |
2019 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Obesity attenuates force-induced tooth movement in mice with the elevation of leptin level: a preliminary translational study.
|
30662654 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with reduced physiological responses to leptin and insulin, leading to the concept of obesity-associated hormonal resistance.
|
30995667 |
2019 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated to a low-grade inflammation that alters the expression of adiponectin, leptin, IL-6, Monocyte Chemotactic Protein 1 (MCP1), TRAIL, LIGHT/TNFSF14, OPG, and TNFα.
|
31130918 |
2019 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Obesity as an Inflammatory Agent Can Cause Cellular Changes in Human Milk due to the Actions of the Adipokines Leptin and Adiponectin.
|
31146419 |
2019 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity as a Risk Factor for Alzheimer's Disease: Implication of Leptin and Glutamate.
|
31191220 |
2019 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity promotes steatosis and is characterized by leptin resistance.
|
31222048 |
2019 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity is unexpectedly associated with improved outcomes with immune and targeted therapy in melanoma, with early mechanistic data suggesting leptin as one mediator.
|
31263961 |
2019 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity increases the risk of cancer.Increased levels of hormones (such as oestrogen, insulin, insulin-like growth factor, and leptin), free fatty acid-induced production of reactive oxygen species, an altered intestinal microbiome and chronic inflammation are known to be associated with an increased cancer risk in obese subjects.
|
31439906 |
2019 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Obesity and diabetes were associated with increased leptin and decreased adiponectin plasma levels, higher protein expression of leptin and IL-6 in SAT, and higher visfatin protein expression in EAT.
|
31533725 |
2019 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with diabetes, and leptin is known to be elevated in obesity.
|
9389736 |
1997 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin and the genetics of obesity.
|
10102052 |
1999 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin resistance and obesity have been related to mutations of the leptin receptor gene in rodents and, recently, in a consanguineous family.
|
10923636 |
2000 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin has a powerful effect on fertility and the initiation of puberty in addition to its effect on obesity.
|
11461187 |
2001 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin resistance in obese individuals is frequently associated with insulin resistance and pronounced hyperinsulinaemia indicating a negative crosstalk of the insulin and leptin signalling chain.
|
11596667 |
2001 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin itself seems ineffective in treating most human obesity, but alternative means of activating appetite-regulatory pathways downstream of leptin are targets for future pharmacological approaches to aid weight loss.
|
11757823 |
2001 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Leptin-deficient mice of the DBA-ob strain have variable obesity-diabetes.
|
12136396 |
2002 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin, an adipocyte product, has been shown to play a role in obesity-related hypertension and in vitro studies demonstrated a biologic interaction between leptin and TGF-beta1.
|
12219869 |
2002 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin's relation with obesity has been clearly demonstrated while its role in oncobiology is still largely unknown.
|
15452447 |
2004 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin plays an important role in the regulation of body fat homeostasis, and potential associations of leptin receptor gene (LEPR) polymorphisms with obesity have been suggested.
|
16011872 |
2006 |