|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Leptin is a circulating hormone and major adiposity signal involved in long-term energy homeostasis.
|
16293682 |
2006 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Leptin controls energy balance and food intake through the leptin receptor in the hypothalamus of the brain, which suggests that some polymorphisms of the leptin receptor gene (LEPR) might contribute to obesity or obesity-related diseases.
|
16333525 |
2006 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin and obesity are clearly related, and obesity is associated with an increased risk of breast cancer.
|
16609020 |
2006 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin brain uptake decreased in women, in the aged, and in more-obese subjects.
|
16944669 |
2006 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk?
|
17425664 |
2007 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin and the pancreatic hormones amylin and pancreatic polypeptide are being evaluated alone or in combination for the treatment of obesity, but their physiological regulation has not yet been fully elucidated.
|
18252898 |
2008 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin is related with obesity and its metabolic disorders.
|
19182739 |
2009 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Leptin expression is up-regulated in obesity and it can promote breast cancer cell growth.
|
20032412 |
2009 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin is elevated in obesity and studies have shown a positive correlation between leptin and PAI-1 levels in human subjects, along with a negative correlation with tissue-type plasminogen activator (tPA).
|
20051227 |
2010 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin resistance underlies the pathogenic development of obesity, which is closely associated with environmental factors.
|
20086094 |
2010 |
|
Obesity
|
0.700 |
Therapeutic
|
disease |
CTD_human |
Leptin-deficient obese (ob/ob) mice and wild-type counterparts (C57/BL6 mice) were exposed to UVB radiation (120 mJ/cm(2)) on alternate days for 1 month.
|
20122948 |
2010 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
Leptin-deficient obese (ob/ob) mice and wild-type counterparts (C57/BL6 mice) were exposed to UVB radiation (120 mJ/cm(2)) on alternate days for 1 month.
|
20122948 |
2010 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin correlates with obesity and insulin resistance, but it remains uncertain whether sOB-R and FLI also do the same.
|
20455195 |
2010 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin and its receptors in obese patients with colorectal cancer.
|
20846476 |
2010 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin, an adipocyte-derived cytokine that is closely associated with obesity, has recently been shown to be involved in carcinogenesis and cancer progression.
|
20945385 |
2011 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Leptin gene variants affect risk of obesity, cancer, but their effect on onset of growth hormone deficiency (GHD) and idiopathic short stature (ISS) is unknown.
|
22350661 |
2012 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin resistance is a common feature of obesity and is accompanied by hyperleptinemia.
|
23256448 |
2013 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Leptin is an adipokine that is secreted by fatty tissue, and high leptin levels are observed both in mouse models of obesity and in obese subjects.
|
23869900 |
2013 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Leptin levels correlated with obesity traits irrespective of the genotypes at the variant positions.
|
24487982 |
2014 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin, an adipocyte-derived cytokine associated with obesity, has been reported to participate in carcinogenesis.
|
24512731 |
2013 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin and vascular cell adhesion molecules-1 (VCAM-1) are two important mediators in obesity-related osteoarthritis, while the molecular mechanism linking leptin to VCAM-1 production is still obscure.
|
24582795 |
2014 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin, a hormone excessively produced during obesity, is suggested to be involved in breast cancer.
|
24738610 |
2014 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population.
|
24947733 |
2014 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin, secreted by the adipose tissue and known to be related to obesity, is considered to be involved in the onset and progression of colorectal cancer.
|
24958593 |
2014 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Leptin links with plasminogen activator inhibitor-1 in human obesity: the SABPA study.
|
25740294 |
2015 |