|
Cachexia
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, IL-6, leptin, adiponectin, and ghrelin are not associated with advanced stages of cancer or cancer-induced cachexia in older subjects with cancer, but they are significantly correlated with anthropometric factors and body composition.
|
31794851 |
2020 |
|
Cachexia
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
There was a significant correlation with cachexia for reduced serum levels of mediators within the glucose utilization [insulin -like growth factor (IGF)-binding protein 6, P = 0·04; IGF-1, P = 0·02], inflammation (lymphotoxin-like inducible protein that competes with glycoprotein D for herpesvirus entry on T cells; LIGHT, P = 0·005), and energy intake/expenditure (leptin, P = 0·004).
|
30941741 |
2019 |
|
Cachexia
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Although circulating levels of leptin and granulocyte-macrophage colony-stimulating factor (GM-CSF) were found to be decreased in the same cohort of treatment-naïve cachectic patients, these factors were closely associated with body mass index, limiting their utility as cancer cachexia biomarkers.
|
29316343 |
2018 |
|
Cachexia
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The recent development of superactive leptin muteins exhibiting antagonistic properties, and other leptin-action-blocking peptides, proteins, monoclonal antibodies, and nanobodies, opens new perspectives for their use in research, and eventually, therapy for cachexia, autoimmune disease, cancer, and other pathologies.
|
24117254 |
2013 |
|
Cachexia
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
We had proposed a central mechanism involving leptin and melanocortin signaling in the pathogenesis of uremic cachexia since agouti-related peptide (AgRP), a melanocortin-4 receptor antagonist, reduced uremic cachexia.
|
18432186 |
2008 |
|
Cachexia
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
The results of this study suggest that elevated circulating levels of cytokines such as leptin may be an important cause of uremia-associated cachexia via signaling through the central melanocortin system.
|
15931394 |
2005 |
|
Cachexia
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Fat mass, leptin, and pseudouridine were significantly different (P < 0.001) between noncachectic patients (NCPs) and cachectic patients (CPs: n = 35); the systemic inflammatory cytokine profile was not.
|
16280439 |
2005 |
|
Cachexia
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The data from the present study indicate that, in gynaecological and breast cancers, leptin is related to hormonal status but not to cachexia.
|
15138597 |
2004 |
|
Cachexia
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Cachexia was associated with atrophy of epidermal and adnexal structures of skin; a similar phenotype is reported in triglyceride-deficient mice and in ob/ob mice injected with leptin.
|
14633625 |
2003 |