Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome.
|
30792083 |
2019 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A Receiver Operator Characteristic curve was used to identify the ability of adiponectin and leptin level to predict the MetS.
|
31341853 |
2019 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The adipokines DPP-4 and leptin in the serum can influence the body fat distribution of patients with T2MD; there is an important association of DPP-4, leptin and ADPN levels with MS, which may be used as therapeutic targets for multiple metabolism disorders of T2MD.
|
29205013 |
2019 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study.
|
31311491 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The addition of leptin and adiponectin to the regression models did not substantially change the impact of thyroid hormones on components of MS. Our data suggest that, even within the euthyroid range, excess of truncal adipose tissue is associated with variations in FT4.
|
31151171 |
2019 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We previously found that blood C-reactive protein (CRP), interleukin-6 (IL-6), and leptin levels were predictors of current metabolic syndrome in schizophrenia.
|
31118157 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively).
|
30530892 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The 8-week individualized training program decreased glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol and leptin in obese subjects with and without MS.
|
30832279 |
2019 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We aimed to explore the association of <i>LEPR</i> polymorphisms with obesity, metabolic syndrome (MetS), and leptin levels in Afro-Caribbean nondiabetic subjects.
|
30807250 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity and the MS are distinguished by an increase in circulating leptin concentrations, in parallel to a drop in the levels of adiponectin.
|
30813240 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine whether MetS has an impact on the global DNA methylation pattern and the DNA methylation of several genes related to adipogenesis (PPARG, PPARA), lipid metabolism (RXRA, SREBF2, SREBF1, SCD, LPL, LXRb), and inflammation (LRP1 C3, LEP and TNF) in visceral adipose tissue.
|
30642114 |
2019 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the circulating miRNA profiles were associated with the plasma leptin level in metabolic syndrome, and miRNAs were found to be involved in hypothalamic leptin sensitivity.
|
31408957 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Understanding the inflammatory effects of leptin on the pulmonary system provides opportunities to develop strategies against lung injury related to metabolic syndrome or obesity.
|
30832310 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
This review provides an updated 'state-of-the-art' about the leptin and its role in the pathophysiology of metabolic syndrome at the molecular level.
|
31154250 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The synovium and IPFP in the MetS-OA group secreted more leptin and less adiponectin than those in the non-MetS-OA group (Leptin: 5.32 vs. 1.28 in synovium, respectively; <i>p</i>= 0.028; 6.44 vs. 0.88 in IPFP, respectively; <i>p</i>= 0.017.
|
31137976 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.
|
31249528 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
High plasma leptin in early adulthood, a risk factor for cardio-metabolic syndrome, was associated with low weight at age two years (correlation coefficient controlled for adult weight = -0.21, p<0.01).
|
31661671 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ARR correlated with the number of variables of MetS (r = 0.191, P = 0.002), body mass index (BMI; r = 0.136, P = 0.026), systolic blood pressure (r = 0.183, P = 0.002), diastolic blood pressure (r = 0.1917, P = 0.0014), potassium excreted fraction (r = 0.174, P = 0.004), low-density lipoprotein (r = 0.156, P = 0.01), plasminogen activator inhibitor type 1 (r = 0.158, P = 0.009), microalbuminuria (r = 0.136, P = 0.029), and leptin (r = 0.142, P = 0.019).
|
30753255 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Significant increases were observed in blood pressure, HOMA-IR, leptin, triglycerides, insulin, intra-abdominal fat, and number of fat cells per field (<i>p</i> = 0.001) and in advanced glycosylation products, adipocyte area, LPL, HSL activities and/or expression (<i>p</i> ≤ 0.01) in the MS groups progressively from the third month onward.
|
31284400 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Linear regression confirmed an independent association of both leptin and hs-CRP with VFth in women, also after adjustment for age and MetS (<i>p</i> = 0.012 and 0.007, respectively).
|
31783662 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
RT-PCR and immunoassy analysis were used to study circulating miRNA profile, adipokines; adiponectin (A), leptin (L), and L/A ratio as well as other factors of metabolic syndrome (MS) in 250 adolescents with severe obesity.
|
30309709 |
2019 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
At baseline, MS was observed in 24 patients, significantly associated with insulin resistance and leptin on multivariate analysis.
|
30054704 |
2018 |
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to compare metabolic aspects potentially associated with metabolic syndrome (MetS), in addition to serum leptin levels and sleep, according to exposure to night work among nursing staff.
|
29580071 |
2018 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, in a metabolic syndrome animal model, the effects of leptin in ventilatory control, carotid sinus nerve activity and adenosine release by the CB are blunted.
|
29271068 |
2018 |
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transcription factors (AMP-activated protein kinase-1, STAT3, sterol regulatory element-binding protein-1 and peroxisome proliferator-activated receptor-γ), leptin and adiponectin receptors seem to be the most promising molecular targets for the therapy of cancers associated with MS.
|
29115033 |
2018 |