Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin.
|
30878306 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Higher pre-treatment leptin was associated with better response to treatment regarding panic symptoms in patients with MDD, while higher IL-6 was associated with worse response regarding panic symptoms in PD patients.
|
31669792 |
2019 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study strongly supports the hypothesis that genetic variability at the leptin locus is involved in lithium augmentation-associated weight gain in major depressive disorder.
|
30554862 |
2019 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
An increase in leptin and insulin levels was observed for both schizophrenia patients (Cohen's d (d): 0.26 and 0.65, respectively) and MDD patients (d: 0.29 and 0.12, respectively) compared to their respective controls.
|
31230885 |
2019 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the elevated plasma leptin levels in the drug-naïve MDD group might be associated with the changes of the white matter integrity in the dorsomedial thalamus region.
|
31354416 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ratio of pre-treatment pBDNF to leptin was significantly lower in patients with MDD and PD compared to healthy controls (p = 0.024), but was not associated with severity of depressive or anxiety symptoms.
|
31465895 |
2019 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There was no association between P-leptin levels and current major depression.
|
30562581 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study examined cross-sectional and longitudinal associations of depressive symptoms and major depressive disorder (MDD) with adiponectin and leptin in healthy middle-aged women (mean (SD) age, 45.6 (2.5) years).
|
30005278 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Plasma leptin levels, psychopathology and biometrics were compared between participants meeting DSM-5 diagnostic criteria for MDD (n = 63) and healthy controls (n = 60).
|
30071417 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Contribution of leptin to MDD has been discovered recently, although the mechanistic links between leptin and the depressive-like behaviors has not been revealed.
|
30666218 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, no significant difference was observed in leptin levels between MDD subjects and HC (SMD = 0.13; 95% CI: -0.06, 0.31; P = 0.170).
|
29870819 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin).
|
29049554 |
2017 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
As compared to control subjects, higher leptin was associated with the atypical MDD subtype both for remitted (n = 144, odds ratio = 1.53, 95% confidence interval = 1.16-2.03, p = .003) and current (n = 270, odds ratio = 1.90, 95% confidence interval = 1.51-2.93, p = 5.3e-8) cases.
|
26742925 |
2017 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results highlight gender differences in determining the association between obesity and depression, and elevated leptin level is a potential mechanism linking MDD to obesity in depressed women.
|
29176959 |
2017 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Reduced brain leptin in patients with major depressive disorder and in suicide victims.
|
16936761 |
2006 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These potential pathways are illustrated with the specific example of the association of the human leptin (OB) gene with obesity and major depressive disorders in humans.
|
9754619 |
1998 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These potential pathways are illustrated with the specific example of the association of the human leptin (OB) gene with obesity and major depressive disorders in humans.
|
9754619 |
1998 |