|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Four-week-old male leptin receptor-knockout db/db mice were used as controls for a model of obesity retaining low testosterone.
|
29895265 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The current study highlights the implication of LEPR mutations in cases of severe early-onset obesity in consanguineous Pakistani families.
|
30442103 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat.
|
29743445 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thus, Cas9-generated Lep and Lepr KO mouse lines will be easier for genotyping, to maintain the lines, and to use for future obesity and diabetes research.
|
29343656 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Young male Zucker rats with a leptin receptor mutation are obese, have a non-insulin-dependent diabetes mellitus (NIDDM), and other endocrinopathies.
|
30339059 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
C-Reactive Protein (CRP) and Leptin Receptor in Obesity: Binding of Monomeric CRP to Leptin Receptor.
|
29910808 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To further define the MC4R pathway and its potential impact on obesity, we tested associations between body mass index (BMI) and LoF mutation burden in the POMC, PCSK1, and LEPR genes in various populations.
|
29726959 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Since leptin deficiency is associated with obesity and other metabolic abnormalities, we generated mice that lack the leptin receptor (LepRb) in cells of the myeloid linage (LysM-LepRb-KO) to evaluate its impact in lean metabolically normal mice in a murine model of pneumococcal pneumonia.
|
29565180 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
In silico design of small peptides antagonist against leptin receptor for the treatment of obesity and its associated immune-mediated diseases.
|
29649778 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
MGD |
Adipocyte Xbp1s overexpression drives uridine production and reduces obesity.
|
29551634 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> We showed that serum miR-27a level correlated positively with obesity and insulin resistance in obese children, and that elevated serum miR-27a levels correlated with insulin resistance in leptin receptor-deficient db/db mice, and with obesity and insulin resistance in high-fat diet-fed C57BL/6J mice.
|
29721071 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Initially to investigate the effect of obesity and IR in the analyzed parameters, insulin-sensitive eutrophic volunteers (CON; <i>n</i> = 9) and obese non-insulin (OB; <i>n</i> = 9) and insulin-resistant (OBR; <i>n</i> = 8) were enrolled.
|
30429793 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Congenital Leptin receptor (LEPR) deficiency is a rare genetic cause of early-onset morbid obesity characterised by severe early onset obesity, major hyperphagia, hypogonadotropic hypogonadism and immune and neuroendocrine/metabolic dysfunction.
|
29545012 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
As regards, rs7799039 AA genotype showed significant higher leptin level than other genotypes in the same group with a non-significant difference in genotypes distribution between obese and controls. rs1137101 variant of leptin receptor and fasting leptin level are correlated with overweight and obesity in Saudi children.
|
29412799 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3'UTR A/C, -2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity.
|
29893028 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cleavage of the leptin receptor by matrix metalloproteinase-2 promotes leptin resistance and obesity in mice.
|
30135249 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the associations between the obesity candidate genes (fat mass and obesity-associated (FTO), melanocortin-4 receptor (MC4R), leptin (LEP) and leptin receptor) and total energy intake and percentage of energy from macronutrients and ultra-processed foods before and during pregnancy.
|
29893663 |
2018 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
J Strength Cond Res 32(4): 1036-1044, 2018-Leptin (LEP) and leptin receptor (LEPR) genes have been studied for their potential association with development of human obesity and its related complications.
|
29373433 |
2018 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We obtained higher serum leptin levels in infants with the GG genotype for Lepr A668G, with haplotype GG/GG for Lep G2548A/A19G, and with GG/GG-GG (LepG2548A/A19G-Lepr A668G); thus, it seems that the genotype GG could be a protector against obesity development in infancy and adulthood.
|
28628399 |
2017 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
LEPR has diverse roles in metabolism, appetite and bone formation with obesity linked to both elevated levels of leptin and increased cancer incidence.
|
29212170 |
2017 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Thus, the aim of the present study is to verify the influence of LEPR polymorphism (rs2767485) on serum orexigenic (NPY, MCH and AgRP) and anorexigenic (Leptin and α-MSH) neuropeptides levels among obese adolescents submitted to 1year of multicomponent weight loss therapy.
|
28801068 |
2017 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Unlike therapeutic interventions that target peroxisome proliferator-activated receptor gamma and leptin receptor activity, which yield detrimental side effects including increased fracture risk and altered feeding behavior, respectively, inhibition of IP6K1 maintains insulin sensitivity and prevents obesity while preserving bone integrity.
|
28577302 |
2017 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of IGF-1 and LEPR indicates a relevant role in androgenic features reversion present in PCOS, hormonal equilibrium, body weight regulation, and glucose metabolism, therefore, under phenotype obesity and infertility regulation in this model.
|
29430464 |
2017 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (<i>db/db</i>).
|
29038790 |
2017 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Through phenotyping of the resulting three lines of rats bearing distinct mutations in the Lepr locus, we found that the strains with a frame-shifted or premature stop codon mutation led to obesity and metabolic disorders.
|
27225180 |
2017 |