|
Filariasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our studies confirm the functionality of BmLec-2 and indicate anti-Lec-2 antibody responses are common in persons with filariasis.
|
31738955 |
2020 |
|
Angiostrongyliasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Application of Recombinant <i>Angiostrongylus cantonensis</i> Galectin-2 Protein for Serodiagnosis of Human Angiostrongyliasis by Immunoblotting.
|
31392957 |
2019 |
|
Angiostrongylus Infections
|
0.010 |
Biomarker
|
disease |
BEFREE |
Application of Recombinant <i>Angiostrongylus cantonensis</i> Galectin-2 Protein for Serodiagnosis of Human Angiostrongyliasis by Immunoblotting.
|
31392957 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have confirmed the involvement of specific proteins previously associated with ALS (Galectin 2 (<i>LGALS3</i>), Transthyretin (<i>TTR</i>), Protein S100-A6 (<i>S100A6</i>), and Protein S100-A11 (<i>S100A11</i>)) and have shown the involvement of proteins not previously described in the ALS context (Methanethiol oxidase (<i>SELENBP1</i>), Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (<i>PIN-1</i>), Calcyclin-binding protein (<i>CACYBP</i>) and Rho-associated protein kinase 2 (<i>ROCK2</i>)).
|
30577465 |
2018 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
There are significant gender-specific expression patterns for single prototype galectins with downregulation of gal-2 and gal-13 of male gender placentas in cases of IUGR.
|
27070577 |
2016 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
All the eight mouse galectin genes were expressed in mammary tumors and tumor epithelial cells (TECs), but galectin-2 and -12 were not detected by western analysis in tumors, and galectin-7 was not detected in 60% of the TEC lines.
|
24037315 |
2013 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
The association of low galectin-2 with LNM was found even in early GCs (p = 0.020).
|
22015694 |
2012 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
The association of low galectin-2 with LNM was found even in early GCs (p = 0.020).
|
22015694 |
2012 |
|
Malaria, Cerebral
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a separate group of Tanzanian children originating from a malaria-endemic region, we found preservation of the major ancestral LGALS2 allele and no association with susceptibility to CM.
|
20500087 |
2010 |
|
Complicated malaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In SM, the C allele at rs7291467 was associated with enhanced galectin-2 transcript levels.
|
20500087 |
2010 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since it has been demonstrated that galectin-2 regulates cell-mediated inflammatory bowel disease and colitis in mice, we intended to investigate the role of galectin-2 in inflammatory cutaneous T cell-mediated immune responses.
|
19380789 |
2009 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Since it has been demonstrated that galectin-2 regulates cell-mediated inflammatory bowel disease and colitis in mice, we intended to investigate the role of galectin-2 in inflammatory cutaneous T cell-mediated immune responses.
|
19380789 |
2009 |
|
Cerebrovascular accident
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The combination of the LGALS2 3279TT and LTA 252GG homozygote was significantly less frequent in the ischemic stroke group (1.56%) than in the controls (5.94%, p<0.00187; overall stroke group: crude OR: 0.25, 95% CI: 0.1-0.64; adjusted OR: 0.03, 95% CI: 0.025-0.71).
|
19013708 |
2009 |
|
Cardiovascular Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The frequency of LGALS2 polymorphisms was similar between RA and controls and was not associated with CVD among patients with RA.
|
18230628 |
2008 |
|
Cerebral Infarction
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome.
|
18506375 |
2008 |
|
Cerebral Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome.
|
18506375 |
2008 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (rs2241883" genes_norm="2168">Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (rs529038" genes_norm="6098">Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction.
|
18506375 |
2008 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
|
19330599 |
2009 |
|
Hypertensive disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated.
|
19330599 |
2009 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The frequency of LGALS2 polymorphisms was similar between RA and controls and was not associated with CVD among patients with RA.
|
18230628 |
2008 |
|
Hypertensive disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (rs2241883" genes_norm="2168">Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (rs529038" genes_norm="6098">Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction.
|
18506375 |
2008 |
|
Metabolic Syndrome X
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome.
|
18506375 |
2008 |
|
Metabolic Syndrome X
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, we used the galectin 2 (LGALS2) genotype, which affects LTA secretion but is located on another chromosome than the HLA gene cluster or TNF, to examine the relationship between the LTA pathway and traits of the metabolic syndrome.
|
16468038 |
2006 |
|
Ischemic stroke
|
0.030 |
Biomarker
|
disease |
BEFREE |
Genetic variation in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) is not a major risk factor for IS.
|
19182073 |
2009 |
|
Ischemic stroke
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we examined whether the LGALS2 3279TT homozygote variant alone can influence the prevalence of ischaemic stroke, and whether it can interact somehow with the disadvantageous LTA 252GG homozygote variant.
|
19013708 |
2009 |