|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that the LTA and LGALS2 polymorphisms affect the subclinical phenotype of the coronary artery, which predisposes to the incidence of MI.
|
22310064 |
2012 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous case-control studies suggested the single nucleotide polymorphisms of lymphotoxin-alpha (LTA) gene and galectin-2 (LGASL2) gene are associated with coronary artery disease and myocardial infarction.
|
19726041 |
2010 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several genes involved in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) have been linked with the risk of myocardial infarction.
|
19182073 |
2009 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We previously reported association of variants in LGALS2, encoding galectin-2, with myocardial infarction susceptibility in a case-control association study in a Japanese population.
|
19198608 |
2009 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated.
|
19330599 |
2009 |
|
Myocardial Infarction
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
By contrast, the galectin-2-encoding gene LGALS2 3279TT homozygote variant has been demonstrated to exert protection against myocardial infarction by reducing the transcriptional level of galectin-2, thereby leading to a reduced extracellular secretion of LTA.
|
19013708 |
2009 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
These observations showed that, while the LTA 252GG genotype might modify the development of coronary atherosclerosis, the relation of LTA and LGALS2 to MI itself remained much less certain.
|
17493152 |
2007 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A putative risk genotype of the polymorphism in the LGALS2 gene (rs7291467; 3279T/C) was not associated with myocardial infarction (OR 0.98, 95% CI 0.83-1.16; P = 0.84).
|
17517687 |
2007 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI.
|
17497114 |
2007 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional SNP (rs7291467) in galectin-2 (LGALS2), a protein involved in the LTA cascade, has been associated with susceptibility to MI in the Japanese population.
|
17098239 |
2007 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic association study again revealed that an SNP in LGALS2 encoding galectin-2 was also associated with susceptibility to MI.
|
16770523 |
2006 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have also been undertaken, and the pro-inflammatory cytokine lymphotoxin-alpha (LTA), and its key ligand galectin-2 (LGALS2) have been identified as genes implicated in predisposition for heart attack.
|
16987874 |
2006 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association study further revealed that a functional SNP in LGALS2 encoding galectin-2, which led to altered secretion of LTA, also indicated a risk of myocardial infarction.
|
15990958 |
2005 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
BEFREE |
Four new susceptibility genes have been identified using genome-wide association studies or genome-wide linkage studies: LTA (encoding cytokine lymphotoxin-alpha) on 6p21.3 for MI; LGALS2 (encoding galectin-2, an LTA-interacting protein) on 22q12-q13 for MI; ALOX5AP (encoding 5-lipoxygenase activating protein involved in synthesizing potent pro-inflammatory leukotrienes) on 13q12-13 for MI and stroke; and PDE4D (encoding phosphodiesterase 4D) on 5q12 for ischemic stroke.
|
15811259 |
2005 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our case-control association study in a Japanese population showed that a single nucleotide polymorphism in LGALS2 encoding galectin-2 is significantly associated with susceptibility to MI.
|
15129282 |
2004 |
|
Myocardial Infarction
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our case-control association study in a Japanese population showed that a single nucleotide polymorphism in LGALS2 encoding galectin-2 is significantly associated with susceptibility to MI.
|
15129282 |
2004 |
|
Myocardial Infarction
|
0.400 |
Biomarker
|
disease |
CTD_human |
Our case-control association study in a Japanese population showed that a single nucleotide polymorphism in LGALS2 encoding galectin-2 is significantly associated with susceptibility to MI.
|
15129282 |
2004 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Necrotizing Enterocolitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding.
|
18806098 |
2008 |
|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Coronary Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients.
|
25884209 |
2015 |
|
Coronary Arteriosclerosis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.
|
26045830 |
2015 |
|
Coronary Artery Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Galectin-2 is a monocyte-expressed carbohydrate-binding lectin, for which increased expression is genetically determined and associated with decreased collateral arteriogenesis in obstructive coronary artery disease patients.
|
25884209 |
2015 |
|
Coronary Artery Disease
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
PPARG, AGTR1, CXCL16 and LGALS2 polymorphisms are correlated with the risk for coronary heart disease.
|
26045830 |
2015 |
|
Coronary Artery Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Modulation of galectin-2 may constitute a new therapeutic strategy for the stimulation of arteriogenesis in patients with CAD.
|
21831908 |
2012 |