Serum Mac-2 binding protein (M2BP) and Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA<sup>+</sup> -M2BP) are used to estimate the liver fibrosis stage in chronic liver diseases.
An assay for Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA<sup>+</sup> -M2BP) has been reported as a useful non-invasive marker for the evaluation of the staging of fibrosis in several chronic liver diseases.
Mac-2 binding protein glycosylation isomer (M2BPGi) is an emerging biomarker for risk prediction of liver disease, but data remain sparse for patients with chronic hepatitis B (CHB) who are treated with nucleos(t)ide analogues (NA).
Sensitivity and specificity of WFA<sup>+</sup> -M2BP for assessing liver fibrosis staging in chronic liver diseases with broad etiologies were determined.