LGALS9, galectin 9, 3965

N. diseases: 197; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027697
Disease: Nephritis
Nephritis 		0.310 Therapeutic disease CTD_human Efficacy of galectins in the amelioration of nephrotoxic serum nephritis in Wistar Kyoto rats. 11044214 2000
CUI: C1306759
Disease: Eosinophilic disorder
Eosinophilic disorder 		0.030 Biomarker group BEFREE There is no information whether galectin-9 (a novel eosinophil chemoattractant) was associated with pathogenesis of eosinophilic disorders. 12037400 2002
CUI: C0002989
Disease: Epithelioid hemangioma of skin
Epithelioid hemangioma of skin 		0.010 AlteredExpression disease BEFREE We assessed the expression of galectin-9 with imunostaining and in situ hybridization both in the lesion of angiolymphoid hyperplasia with eosinophilia, and peripheral blood eosinophils of eosinophilic patients (E-Eos) in comparison with those of normal volunteers (N-Eos). 12037400 2002
CUI: C0205788
Disease: Histiocytoid hemangioma
Histiocytoid hemangioma 		0.010 AlteredExpression disease BEFREE We assessed the expression of galectin-9 with imunostaining and in situ hybridization both in the lesion of angiolymphoid hyperplasia with eosinophilia, and peripheral blood eosinophils of eosinophilic patients (E-Eos) in comparison with those of normal volunteers (N-Eos). 12037400 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Association of galectin-9 expression in melanoma cells with prognosis of the patients bearing melanocytic tumors was further examined. 12115481 2002
CUI: C0025202
Disease: melanoma
melanoma 		0.060 AlteredExpression disease LHGDN High galectin-9 expression was inversely correlated with the progression of this disease, suggesting that high galectin-9 expression in primary melanoma lesions links to a better prognosis. 12115481 2002
CUI: C0025202
Disease: melanoma
melanoma 		0.060 AlteredExpression disease BEFREE Association of galectin-9 expression in melanoma cells with prognosis of the patients bearing melanocytic tumors was further examined. 12115481 2002
CUI: C0027962
Disease: Melanocytic nevus
Melanocytic nevus 		0.010 AlteredExpression disease BEFREE Galectin-9 protein was strongly and homogeneously expressed in melanocytic nevi, but down-regulated in melanoma cells especially in metastatic lesions. 12115481 2002
CUI: C3665593
Disease: Melanocytic nevus of skin
Melanocytic nevus of skin 		0.010 AlteredExpression disease BEFREE Galectin-9 protein was strongly and homogeneously expressed in melanocytic nevi, but down-regulated in melanoma cells especially in metastatic lesions. 12115481 2002
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases 		0.010 AlteredExpression group BEFREE Furthermore, significant up-regulation of galectin-9 mRNA expression was detected in the mRNA from PDLs of patients with periodontal disease when compared with healthy donors (P < 0.05). 15474984 2005
CUI: C0031094
Disease: Periodontal Pocket
Periodontal Pocket 		0.010 Biomarker disease BEFREE In addition, strong immunoreaction for galectin-9 was detected in the PDL consisting of the periodontal pocket of a patient with severe periodontal disease. 15474984 2005
CUI: C4025886
Disease: Severe periodontitis
Severe periodontitis 		0.010 Biomarker disease BEFREE In addition, strong immunoreaction for galectin-9 was detected in the PDL consisting of the periodontal pocket of a patient with severe periodontal disease. 15474984 2005
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE We assessed the contribution of galectin-9 to the aggregation of breast cancer cells as well as the relation between galectin-9 expression in tumor tissue and distant metastasis in patients with breast cancer. 15837748 2005
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 Biomarker phenotype BEFREE Tumors of 42 of the 84 patients were galectin-9 positive, and those of 19 of the 21 patients with distant metastasis were galectin-9 negative. 15837748 2005
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.050 Biomarker disease BEFREE Multivariate analysis revealed that galectin-9 status influenced distant metastasis independently of and to a greater extent than lymph node metastasis. 15837748 2005
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE The tumors of 84 patients with breast cancer were tested for galectin-9 expression by immunohistochemistry. 15837748 2005
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE The tumors of 84 patients with breast cancer were tested for galectin-9 expression by immunohistochemistry. 15837748 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.020 Biomarker group LHGDN Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer. 15837748 2005
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 AlteredExpression phenotype LHGDN The data suggest that galectin-9 is correlated with oral cancer cell-matrix interactions and may therefore play an important role in the metastasis of OSCCs. 16012760 2005
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 Biomarker phenotype BEFREE The data suggest that galectin-9 is correlated with oral cancer cell-matrix interactions and may therefore play an important role in the metastasis of OSCCs. 16012760 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 AlteredExpression disease LHGDN Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. 16012760 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 Biomarker disease BEFREE Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. 16012760 2005
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms 		0.010 Biomarker group LHGDN Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. 16012760 2005
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.030 Biomarker disease BEFREE Galectin 9 is abundant in NPC biopsies as well as in LCLs, whereas it is absent in Burkitt lymphoma cells. 16227255 2005
CUI: C4727981
Disease: Eosinophilic otitis media
Eosinophilic otitis media 		0.010 AlteredExpression disease BEFREE Immunohistochemically, the numbers of cells positive for EG2 and ecalectin were significantly higher in the EOM patients than in the controls. 16238798 2005