LGALS9, galectin 9, 3965

N. diseases: 197; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.010 AlteredExpression disease BEFREE Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells. 25880730 2015
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Cancer Therapy Due to Apoptosis: Galectin-9. 28045432 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Cancer Therapy Due to Apoptosis: Galectin-9. 28045432 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response. 31720813 2019
CUI: C0027962
Disease: Melanocytic nevus
Melanocytic nevus 		0.010 AlteredExpression disease BEFREE Galectin-9 protein was strongly and homogeneously expressed in melanocytic nevi, but down-regulated in melanoma cells especially in metastatic lesions. 12115481 2002
CUI: C3665593
Disease: Melanocytic nevus of skin
Melanocytic nevus of skin 		0.010 AlteredExpression disease BEFREE Galectin-9 protein was strongly and homogeneously expressed in melanocytic nevi, but down-regulated in melanoma cells especially in metastatic lesions. 12115481 2002
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 AlteredExpression disease LHGDN Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. 16012760 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 Biomarker disease BEFREE Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. 16012760 2005
CUI: C2931822
Disease: Nasopharyngeal carcinoma
Nasopharyngeal carcinoma 		0.030 Biomarker disease BEFREE Galectin 9 is abundant in NPC biopsies as well as in LCLs, whereas it is absent in Burkitt lymphoma cells. 16227255 2005
CUI: C0206708
Disease: Cervical Intraepithelial Neoplasia
Cervical Intraepithelial Neoplasia 		0.010 AlteredExpression disease LHGDN Gal-9 and E-cadherin were evidently detected in normal epithelium and endocervical glands, but those in CIN and SCC were significantly faint. 18264727 2008
CUI: C3160909
Disease: Autoimmune arthritis
Autoimmune arthritis 		0.010 Biomarker disease BEFREE Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. 18282810 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.060 Biomarker disease BEFREE Gal-9-mediated apoptosis of CD4+ T cells is dysfunctional in RA patients. 21717191 2012
CUI: C0151517
Disease: Complete atrioventricular block
Complete atrioventricular block 		0.010 Biomarker disease BEFREE Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. 23112829 2012
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.030 Biomarker group BEFREE Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. 23112829 2012
CUI: C0747845
Disease: early pregnancy
early pregnancy 		0.030 AlteredExpression phenotype BEFREE Galectin-9 (LGALS9), a tandem repeat lectin associated with immune modulation, is expressed in the endometrium during the mid and late secretory phases and in decidua during human early pregnancy. 23242525 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.090 Biomarker phenotype BEFREE Galectin-9, encoded by LGALS9, has been associated with metastasis and immunosuppression. 24333696 2014
CUI: C4048329
Disease: Immunosuppression
Immunosuppression 		0.020 Biomarker disease BEFREE Galectin-9, encoded by LGALS9, has been associated with metastasis and immunosuppression. 24333696 2014
CUI: C0155686
Disease: Acute myocarditis
Acute myocarditis 		0.010 Biomarker disease BEFREE Galectin-9 induced myeloid suppressor cells expand regulatory T cells in an IL-10-dependent manner in CVB3-induced acute myocarditis. 24573249 2014
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.040 Biomarker disease BEFREE Galectin-9 is rapidly released during acute HIV-1 infection and remains sustained at high levels despite viral suppression even in elite controllers. 24786365 2014
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE Galectin-9 (Gal-9), a member of animal lectin family with evolutionary conserved carbohydrate recognition domains, has been reported to exert a large variety of functional roles in tumorigenesis due to its β-galactoside-binding affinity. 25716202 2015
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Galectin-9, a soluble β-galactoside-binding animal lectin, evokes apoptosis in various human cancer cell lines. 25823465 2015
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Galectin-9, a soluble β-galactoside-binding animal lectin, evokes apoptosis in various human cancer cell lines. 25823465 2015
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Galectin-9 (Gal-9) plays an important role in both the immune response and tumor progression, while microRNAs act as tumor regulators to mediate tumorigenesis. 26239725 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.040 Biomarker phenotype BEFREE Galectin-9 (Gal-9) plays an important role in both the immune response and tumor progression, while microRNAs act as tumor regulators to mediate tumorigenesis. 26239725 2015
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.050 AlteredExpression disease BEFREE Galectin-9 mRNA increased 8-fold when primary monocytes were exposed to hepatitis C virus--infected cells. 26475932 2016