Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein B (APOB), and hepatic lipase (LIPC) genes have been shown to play a key role in lipid metabolism in type 2 diabetes (T2D).
|
29883758 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Functional characterization of novel variants in the CETP promoter and the LIPC gene in subjects with hyperalphalipoproteinemia.
|
23219720 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
The LIPC -250G>A (rs2070895) variant was genotyped in the Inter99 study (n = 6070), the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen Detected Diabetes in Primary Care Denmark screening cohort of individuals with risk factors for undiagnosed type 2 diabetes (n = 8662), and in additional type 2 diabetic patients (n = 1,064) and glucose-tolerant control subjects (n = 360).
|
18364377 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
AlteredExpression
|
disease |
BEFREE |
Elevated hepatic lipase (HL, also known as LIPC) expression is a key factor in the development of the atherogenic lipid profile in type 2 diabetes and insulin resistance.
|
18758746 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
Patients with type 2 diabetes who are carriers of the rare -250A allele in the promoter of the hepatic lipase gene are susceptible to PAD.
|
18413186 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
The G-250A promoter polymorphism of the LIPC gene is associated with an increased risk of development of type 2 diabetes in high-risk subjects with IGT.
|
15656877 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
Biomarker
|
disease |
CTD_human |
The G-250A promoter polymorphism of the LIPC gene is associated with an increased risk of development of type 2 diabetes in high-risk subjects with IGT.
|
15656877 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
Biomarker
|
disease |
CTD_human |
We investigated whether the G-250A polymorphism of the hepatic lipase gene (LIPC) predicts the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in the Finnish Diabetes Prevention Study.
|
15126514 |
2004 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the G-250A polymorphism of the hepatic lipase gene (LIPC) predicts the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in the Finnish Diabetes Prevention Study.
|
15126514 |
2004 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
Little is known about the effect of cholesterol synthesis inhibitors on HL activity in relation to sex and the hepatic lipase gene, the LIPC promoter variant in type 2 diabetes.
|
12547874 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, despite the higher frequency of the T allele in Chinese than in Caucasians, gender was the best predictor for HL activity, with LIPC gene polymorphism and type 2 diabetes making relatively smaller contributions to the variation in HL activity.
|
11427226 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
Biomarker
|
disease |
HPO |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.680 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|