SHC4, SHC adaptor protein 4, 399694

N. diseases: 12; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0523465
Disease: Serum albumin measurement
Serum albumin measurement 		0.100 GeneticVariation phenotype GWASDB A genome-wide assessment of variability in human serum metabolism. 23281178 2013
CUI: C0027404
Disease: Narcolepsy
Narcolepsy 		0.100 GeneticVariation disease GWASDB Genome-wide association database developed in the Japanese Integrated Database Project. 19629137 2009
CUI: C0037290
Disease: Skin Pigmentation
Skin Pigmentation 		0.100 GeneticVariation phenotype GWASDB A genomewide association study of skin pigmentation in a South Asian population. 17999355 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.020 Biomarker disease BEFREE While implication with BD is novel, COPS2, EID1, and SHC4 are known to be relevant for neuronal differentiation and function and DTWD1 for psychopharmacological side effects. 30503783 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.020 Biomarker disease BEFREE SHC4 gene was associated with depressive symptoms severity in BP (p = .003). 30149091 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 Biomarker disease BEFREE SHC4 regulates BDNF-induced MAPK activation and was previously associated with depression. 30149091 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 Biomarker disease BEFREE SHC4 regulates BDNF-induced MAPK activation and was previously associated with depression. 30149091 2019
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.010 Biomarker phenotype BEFREE SHC4 gene was associated with depressive symptoms severity in BP (p = .003). 30149091 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 Biomarker phenotype BEFREE SHC4 regulates BDNF-induced MAPK activation and was previously associated with depression. 30149091 2019
CUI: C0021167
Disease: Incontinence
Incontinence 		0.010 Biomarker disease BEFREE Incontinence rates at 3 and 12 months after RRP decreased from 67.6% to 10.1 and after RALP decreased from 53.4% to 5.4%. 29039893 2018
CUI: C0332853
Disease: Anastomosis
Anastomosis 		0.010 Biomarker disease BEFREE After a Rocco suture was applied, and then urethrovesical anastomosis was performed with continuous suture as for RALP. 29039893 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE At multivariable analysis the factors related to the risk of PSM were stage pT>2 (RR 2.979, P=0.001), Gleason Score >6 (RR 1.662, P=0.026), the volume of tumor (RR 1.019, P=0.008) and the surgical technique (RALP vs. RRP, RR 0.647, P=0.039). 28009146 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.010 AlteredExpression disease BEFREE Analysis of RaLP expression during the melanoma progression revealed low expression in normal melanocytes and benign nevi, whereas high levels of RaLP protein were found at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential. 17409413 2007