CASC15, cancer susceptibility 15, 401237

N. diseases: 90; N. variants: 46
Disease: Neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 Biomarker disease BEFREE We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. 29533783 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 Biomarker disease BEFREE Previous research shows that lncRNA CASC15 is implicated in the biological behaviors of several cancers such as neuroblastoma and melanoma. 29489064 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASCAT Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma. 28545128 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease BEFREE We confirmed that CASC15 rs6939340 A>G, rs4712653 T>C, rs9295536 C>A, LIN28B rs221634 A>T, and LMO1 rs110419 A>G were associated with significantly altered neuroblastoma susceptibility. 29024823 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASCAT Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk. 28924153 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 AlteredExpression disease BEFREE Gene expression analysis revealed downregulation of neuroblastoma-specific markers in cells with attenuated CASC15-S, with concomitant increases in cell adhesion and extracellular matrix transcripts. 26100672 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease BEFREE In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability. 25312269 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease BEFREE Several neuroblastoma (NB) susceptibility loci have been identified within LINC00340, BARD1, LMO1, DUSP12, HSD17B12, DDX4, IL31RA, HACE1 and LIN28B by genome-wide association (GWA) studies including European American individuals. 23222812 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASCAT Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. 22941191 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASDB Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. 22941191 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASDB Integrative genomics identifies LMO1 as a neuroblastoma oncogene. 21124317 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASCAT Integrative genomics identifies LMO1 as a neuroblastoma oncogene. 21124317 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASDB Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. 18463370 2008
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.160 GeneticVariation disease GWASCAT Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. 18463370 2008