LOX, lysyl oxidase, 4015

N. diseases: 328; N. variants: 14
Disease: Non-Small Cell Lung Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 Biomarker disease BEFREE Mechanistically, we demonstrated a novel FOXC1-LOX mechanism that was involved in the invasion and metastasis of NSCLC. 31597217 2019
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 AlteredExpression disease BEFREE Moreover, we confirmed that LOX expression is regulated by the activation of epidermal growth factor receptor (EGFR) via the PI3K/AKT, MEK/ERK, and SAPK/JNK signaling pathways in non-small cell lung cancer (NSCLC). 29472856 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 AlteredExpression disease BEFREE The relative mRNA expression or protein expression of LOX were significantly higher in NSCLC tumor tissues than in the corresponding noncancerous tissues (P < 0.05). 25337249 2014
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 AlteredExpression disease BEFREE The expression of HIF-1α and LOX had a significant inverse impact on survival of patients with NSCLC. 23886154 2013
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 Biomarker disease BEFREE However, the role and molecular mechanism by which LOX involving in hypoxic NSCLC invasion and migration are poorly understood. 23140307 2012
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.060 GeneticVariation disease BEFREE These data indicate that LOX 473 G/A polymorphism is associated with increased risk of NSCLC and can be a prognostic predictor for this disease. 22948781 2012