LOX, lysyl oxidase, 4015

N. diseases: 328; N. variants: 14
Disease: Pulmonary Fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 Biomarker disease BEFREE LOX/LOXL in pulmonary fibrosis: potential therapeutic targets. 30457362 2019
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 Biomarker disease BEFREE The association between HIF-1α and LOX in regulating EMT during PQ-induced PF may be unidirectional. 29467842 2018
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 Biomarker disease BEFREE This study aimed to further our understanding of the mechanisms by which LO inhibitors might improve lung fibrosis. 29125826 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 Biomarker disease BEFREE Lysyl oxidase‑like 2 (LOXL2), which is involved in invasive growth and metastasis of malignant neoplasms, has recently been reported to serve a key role in hepatic and pulmonary fibrosis. 28677767 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 AlteredExpression disease BEFREE Here, we systematically investigated LOX/L expression in primary fibroblasts and epithelial cells under fibrotic conditions, Bleomycin (BLM) induced lung fibrosis and in human IPF tissue. 28273952 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 AlteredExpression disease BEFREE In vivo, romidepsin inhibited bleomycin-induced pulmonary fibrosis in association with suppression of LOX expression. 28467787 2017
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 AlteredExpression disease BEFREE Bleomycin induces upregulation of LO in cultured human fetal lung fibroblasts, which may be the mechanism of bleomycin-induced pulmonary fibrosis. 20418892 2010
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.080 Biomarker disease BEFREE LOL protein and LO were colocalized at sites of fibrogenesis in human lung fibrosis and in the stromal reaction of bronchiolo-alveolar carcinomas and of in situ ductal breast tumors. 9484712 1998