LOX, lysyl oxidase, 4015

N. diseases: 328; N. variants: 14
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 Biomarker disease BEFREE Lysyl oxidase assists tumor‑initiating cells to enhance angiogenesis in hepatocellular carcinoma. 30720077 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 Biomarker disease BEFREE These findings indicate that lysyl oxidase could be a potential therapeutic target for early recurrence of HCC. 30919528 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 AlteredExpression disease BEFREE Significance of Lysyl oxidase‑like 2 gene expression on the epithelial‑mesenchymal status of hepatocellular carcinoma. 29620290 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 Biomarker disease BEFREE LOX-1<sup>+</sup>  CD15<sup>+</sup> PMN-MDSC in circulation were positively associated with those in HCC tissues. 29211299 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 Biomarker disease BEFREE More intriguingly, overexpression of HBx elevated the mRNA and protein expression of a family of HIF-1α target genes, the lysyl oxidase (LOX) family in HCC. 29799025 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 Biomarker disease BEFREE Lysyl oxidase-like 2 (LOXL2) is key in the hepatocellular carcinoma (HCC) tumor microenvironment and metastatic niche formation. 27430160 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 AlteredExpression disease BEFREE Our study showed that LOX was up-regulated in HCC cell lines and tissue. 26048020 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.080 AlteredExpression disease BEFREE This study suggests that targeting LOX expression with food components such as PSB and curcumin may be a novel strategy to overcome ethanol-induced HCC cell metastasis in liver cancer patients. 23560895 2013