LPA, lipoprotein(a), 4018

N. diseases: 340; N. variants: 49
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Alirocumab significantly reduced other lipid/lipoproteins (including lipoprotein[a]) similarly in patients with/without MI/ischemic stroke. 31076261 2020
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Causal Effect of Lp(a) [Lipoprotein(a)] Level on Ischemic Stroke and Alzheimer Disease: A Mendelian Randomization Study. 31597550 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE The purpose of this study was to test if high lipoprotein(a) is associated with high risk of ischemic stroke observationally and causally from human genetics. 31272552 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Lipoprotein(a) and Risk of Ischemic Stroke in the REGARDS Study. 30786745 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Lipoprotein (a) as a Predictor of Early Stroke Recurrence in Acute Ischemic Stroke. 28004340 2018
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Elevated Lipoprotein (a) and Risk of Poor Functional Outcome in Chinese Patients with Ischemic Stroke and Type 2 Diabetes. 29264843 2018
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Case report of male child with elevated lipoprotein (a) leading to acute ischemic stroke. 28139007 2017
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Lipoprotein(a) Levels and Recurrent Vascular Events After First Ischemic Stroke. 27856951 2017
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Elevated serum lipoprotein(a) as a risk factor for combined intracranial and extracranial artery stenosis in a child with arterial ischemic stroke: A case report. 29245288 2017
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Associations of Lipoprotein(a) Levels With Incident Atrial Fibrillation and Ischemic Stroke: The ARIC (Atherosclerosis Risk in Communities) Study. 29246963 2017
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (n(e) = 4,572); venous thromboembolism (n(e) = 4,607); intracranial aneurysm (n(e) = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). 22898070 2012
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Raised lipoprotein (a), protein C deficiency, and stroke of vascular origin are risk factors for recurrent arterial ischaemic stroke in childhood. 12443591 2002
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Available evidence indicates that factor V Leiden, prothrombin 20210A, and lipoprotein (a) are all important in the pathogenesis of arterial ischemic stroke in older children, but the role of other plasma-phase risk factors remains uncertain. 11923626 2002
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Apolipoprotein(a) size polymorphism in young adults with ischemic stroke. 9920527 1999
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE While FV G1691A and prothrombin G20210 A mutations show no significant data in our study, lipoprotein (a) levels >30 mg/dl protein C deficiency, anticardiolipin antibodies and combined prothrombotic disorders seem to be important risk factors for manifestation of ischaemic strokes in children with underlying cardiac disorders. 10650850 1999
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Lipoprotein (a) and genetic polymorphisms of clotting factor V, prothrombin, and methylenetetrahydrofolate reductase are risk factors of spontaneous ischemic stroke in childhood. 10572079 1999
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 AlteredExpression disease BEFREE Plasma lipoprotein(a) levels in subjects attending a metabolic ward. Discrimination between individuals with and without a history of ischemic stroke. 8548412 1996
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 GeneticVariation disease BEFREE Over a 2-year period the Arg506 to Gln mutation, factor V, protein C, protein S, antithrombin, antiphospholipid antibodies and lipoprotein (a) [Lp(a)] were measured in 14 infants and children with acute ischaemic stroke. 8958390 1996
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke
0.100 Biomarker disease BEFREE Lipoprotein and apolipoprotein profile in men with ischemic stroke. Role of lipoprotein(a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. 1440702 1992