|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Vitamin D (VD) was suggested to have both direct and indirect effects on modifying lipid profile in patients with diabetes through its regulatory action that increases the activity of lipoprotein lipase in adiposity.
|
31266036 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The siRNA against lncRNA-MIAT, miR-328a-5p mimic and overexpression vector of LPL were transfected to investigate the specific effects of miR-328a-5p, lncRNA-MIAT and LPL on ED in diabetes.
|
30660685 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Three proteins, lipoprotein lipase, IGF-binding protein 2 and paraoxonase 3 (PON-3), were inversely associated with diabetes.
|
31446444 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipoprotein lipase (LPL)-mediated hydrolysis of circulating triglycerides is suggested to be the predominant source of FA for cardiac utilization during diabetes.
|
28986359 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the independent and combined associations of genetically determined differences in LPL-mediated lipolysis and low-density lipoprotein cholesterol (LDL-C) metabolism with risk of coronary disease and diabetes.
|
30326043 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human lipoprotein lipase (LPL) is a therapeutic target for obesity, and inhibition of LPL with the approved small molecule agent orlistat has been widely used in clinic to treat obesity-related health problems such as diabetes and cardiovascular diseases.
|
27097985 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knowledge of these intrinsic and extrinsic factors could be used develop therapeutic targets to normalize LPL function, and maintain cardiac energy homeostasis after diabetes.
|
25463481 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipolytic activities in AT are differently altered in obesity and Type 2 diabetes being HSL alteration associated with both insulin-resistant conditions and LPL with diabetes per se.
|
20926921 |
2011 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that D9N polymorphism can be a useful risk marker for myocardial infarction and that further potential candidate genes should be screened for exploratory analysis and for future therapeutic intervention in diabetes.
|
18823627 |
2009 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Dilated lipotoxic cardiomyopathy, thought to be the result of diabetes and severe obesity, has been modeled in several genetically altered mice, including animals with cardiac-specific overexpression of glycosylphosphatidylinositol (GPI)-anchored human lipoprotein lipase (LpL(GPI)).
|
18515784 |
2008 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we present evidence that combinations of SNPs in APOE and LPL identify subgroups of individuals at substantially increased risk of IHD beyond that associated with smoking, diabetes and hypertension.
|
17006673 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiple linear regression identified a significant interaction between LPL HindIII and statin treatment, which together with sex and diabetes explained 12.1% of HDL-C variance.
|
17721767 |
2007 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the H+ allele of the LPL gene HindIII polymorphism is associated with higher plasma triglyceride and lower HDL-cholesterol levels in Chinese patients with early-onset diabetes.
|
12647273 |
2003 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic defects in the LPL gene that could lead to this lower LPL tended to be more frequently observed in patients without diabetes.
|
12876415 |
2003 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the effects of diabetes on lipoprotein profiles and atherosclerosis in a rodent model, we crossed mice that express human apolipoprotein B (HuB), mice that have a heterozygous deletion of lipoprotein lipase (LPL1), and transgenic mice expressing human cholesteryl ester transfer protein (CETP).
|
12032161 |
2002 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since, to the best of our knowledge, there are no data concerning LPL secreted by macrophages of NIDDM patients we conducted a study to assess the expression and activity of LPL secreted by monocyte-derived macrophages from NIDDM patients with cardiovascular complications versus cardiovascular patients without diabetes (controls).
|
11058715 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effects of diabetes and lipoprotein lipase (LpL) on plasma lipids were studied in mice expressing human apolipoprotein B (HuBTg).
|
10588944 |
1999 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Common DNA polymorphisms at the lipoprotein lipase gene. Association with severity of coronary artery disease and diabetes.
|
8641022 |
1996 |