|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using APSampler software, we found composite markers associated with MI only in patients with early onset: FGB rs1800788*T + TGFB1 rs1982073*T; FGB rs1800788*T + LPL rs328*C + IL4 rs2243250*C; FGB rs1800788*T + ENOS rs2070744*C (Fisher p values of 1.4 × 10<sup>-6</sup> to 2.2 × 10<sup>-5</sup>; the permutation p values of 1.1 × 10<sup>-5</sup> to 3.0 × 10<sup>-4</sup>; ORs = 2.67-2.54).
|
28685248 |
2017 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI.
|
25738804 |
2015 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Minor-allele carrier status at the LPL SNP was associated with a reduced risk of myocardial infarction in active (hazard ratio, 0.51; 95% confidence interval 0.30-0.86) but not among inactive women (hazard ratio 1.13; 95% confidence interval 0.79 to 1.61; P-interaction=0.007).
|
21252145 |
2011 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that D9N polymorphism can be a useful risk marker for myocardial infarction and that further potential candidate genes should be screened for exploratory analysis and for future therapeutic intervention in diabetes.
|
18823627 |
2009 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Decreased postheparin LPL activity was accompanied by significantly increased and delayed clearance of postprandial TRL and subsequent lower fasting HDL cholesterol in offspring of MI patients.
|
18194851 |
2008 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
LPL HindIII polymorphism showed significant association of the H(+) allele with myocardial infarction.
|
17484619 |
2007 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
LPL HindIII polymorphism showed significant association of the H(+) allele with myocardial infarction.
|
17484619 |
2007 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction.
|
16519597 |
2006 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
The genotypes for MTHFR, LPL, and IPF1 may prove reliable for assessment of genetic risk for myocardial infarction.
|
16894468 |
2006 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The X447 mutant allele of the LPL gene may protect from MI risk, although this effect is small.
|
15292372 |
2004 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Finally, the lipoprotein lipase Asn291Ser and T4509C (PvuII) polymorphisms did not produce clear effects on either the plasma apoB/apoA(1) ratio or the risk of MI.
|
15256516 |
2004 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The X447 mutant allele of the LPL gene may protect from MI risk, although this effect is small.
|
15292372 |
2004 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, measures of CAD extent showed no differences between LPL quartiles (P>0.30 for prior myocardial infarction, number of diseased vessels, Gensini and extent scores).
|
12048130 |
2002 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
In conclusion, LPL 9N carrier status was unequivocally related to premature CHD and to MI in males, strongly supporting recent results in older aged males.
|
11427211 |
2001 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein lipase gene polymorphism, cholesterol subfractions and myocardial infarction in large samples of the general population.
|
10974229 |
2000 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we demonstrated that the homozygous form of the LPL HindIII(+) allele increases the risk of multivessel disease by a factor of 4 in an Italian group of young MI survivors.
|
10484057 |
1999 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The H-allele of the intron 8 HindIII polymorphism in the lipoprotein lipase (LPL) gene has been associated with a lower risk of myocardial infarction (MI) and plasma levels of triglycerides (TG).
|
9555857 |
1998 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the LPL-D9N mutation in the lipoprotein lipase gene and plasma lipid traits in myocardial infarction survivors from the ECTIM Study.
|
8724108 |
1996 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated associations of LPL polymorphisms (HindIII, PvuII, Ser447-->Ter) and the newly described mutation Asn291-->Ser with the risk of myocardial infarction (MI), severity of atherosclerosis, and fasting plasma lipoprotein concentrations in the ECTIM study (614 patients and 733 controls).
|
8576640 |
1995 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the lipoprotein lipase (LPL) gene, resulting in the substitution of asparagine by serine at residue 291 (LPL-S291), was found to occur in young survivors of a myocardial infarction from Sweden, combined hyperlipidemic subjects from the United Kingdom, and type III hyperlipidemic subjects from Germany at allelic carrier frequencies no different from those found in companion healthy control subjects (3.63 vs. 3.37; 1.85 vs. 1.60; and 2.00 vs. 1.56%, respectively).
|
8576637 |
1995 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association studies were carried out in a sample of 86 patients from Sweden who had survived a myocardial infarction (MI) at a young age and 93 age-matched healthy individuals, to compare the impact of polymorphisms at the apolipoprotein (apo) AI-CIII-AIV gene cluster on among-individual differences in plasma lipid and lipoprotein traits, the five high density lipoprotein (HDL) subclasses (2b to 3c), lipoprotein lipase (LPL) activity and presence and progression of atherosclerosis.
|
7834891 |
1994 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association studies were carried out on a sample of 87 patients from Sweden who had survived a myocardial infarction (MI) at a young age and 93 age-matched healthy individuals, to compare the impact of polymorphisms (PvuII, HindIII and Serine447-Stop) at the lipoprotein lipase (LPL) gene locus on among-individual differences in plasma lipid traits and progression of atherosclerosis.
|
1466662 |
1992 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|