|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
The authors sought to develop combined positron emission tomography (PET) dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to quantify plaque inflammation, permeability, and burden to evaluate the efficacy of a leukotriene A4 hydrolase (LTA4H) inhibitor in a rabbit model of atherosclerosis.
|
29413439 |
2018 |
|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
CTD_human |
The abundant expression of LTA4H and correlation with plaque instability identify LTA4H as a potential target for pharmacological intervention in treatment of human atherosclerosis.
|
16698924 |
2006 |
|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
Recently, leukotriene-based inflammation has also been shown to play an important role in atherosclerosis: ALOX5AP and LTA4H, both genes in the leukotriene biosynthesis pathway, have individually been shown to be associated with various cardiovascular disease (CVD) phenotypes.
|
19130089 |
2009 |
|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis.
|
25721704 |
2015 |
|
Mental Depression
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
We examined the association, separately in men and women, between seven single nucleotide polymorphisms (SNPs) in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and 12 SNPs in the leukotriene A4 hydrolase (LTA4H) gene and depression in 1368 white subjects (30.4% female) referred for cardiovascular evaluation.
|
19622707 |
2009 |
|
Mental Depression
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We examined the association, separately in men and women, between seven single nucleotide polymorphisms (SNPs) in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and 12 SNPs in the leukotriene A4 hydrolase (LTA4H) gene and depression in 1368 white subjects (30.4% female) referred for cardiovascular evaluation.
|
19622707 |
2009 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We examined the association, separately in men and women, between seven single nucleotide polymorphisms (SNPs) in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and 12 SNPs in the leukotriene A4 hydrolase (LTA4H) gene and depression in 1368 white subjects (30.4% female) referred for cardiovascular evaluation.
|
19622707 |
2009 |
|
Depressive disorder
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
We examined the association, separately in men and women, between seven single nucleotide polymorphisms (SNPs) in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and 12 SNPs in the leukotriene A4 hydrolase (LTA4H) gene and depression in 1368 white subjects (30.4% female) referred for cardiovascular evaluation.
|
19622707 |
2009 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Asthma
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that LTA4H A-9188>G, TNFα G-308>A and IL-4Rα A1727>G polymorphisms were significantly associated with the development of difficult asthma in paediatric patients (p<0.001, p = 0.019 and p = 0.037, respectively).
|
23573270 |
2013 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
RGD |
The expression of 5-LO and LTA4-H mRNA, and 5-LO protein levels were increased in lung tissue and cerebral cortex in asthma rats.
|
15715933 |
2005 |
|
Asthma
|
0.280 |
AlteredExpression
|
disease |
BEFREE |
LPS induced significant expression of ANXA1 and LTA4H in asthmatics when compared to COPD patients and healthy subjects.
|
25634111 |
2014 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
These data suggest that polymorphisms spanning ALOX5AP, LTA4H and the LTB4R locus are not major determinants of baseline lung function in smokers, but provide tentative evidence for LTA4H rs1978331C (intron 11) in determining baseline FEV1 and FEV1/FVC ratio in Caucasian Smokers in addition to our previously identified role in asthma susceptibility.
|
22206291 |
2011 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
ALOX5AP and LTA4H are associated with asthma susceptibility, suggesting a role for LTB4 in disease.
|
23167751 |
2012 |
|
Asthma
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
To assess the contribution of LTA4H and ALOX5AP polymorphism to asthma and allergy susceptibility.
|
18547289 |
2008 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
This region harbours a number of candidate genes for asthma and atopy, including stem cell factor (SCF), leukotriene A4 hydrolase (LTA4H), thyroid receptor 2 (TR2), and signal transducer and activator of transcription 6 (STAT6).
|
11069563 |
2000 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma.
|
30352167 |
2019 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
LHGDN |
Single point analyses identified association (P < 0.05) between SNPs SG13S114, SG13S89, SG13S41 (ALOX5AP), rs1978331 (LTA4H) and asthma and/or related phenotypes.
|
18547289 |
2008 |
|
Asthma
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs within LTA4H (rs17525488 and rs2540493) were protective for asthma in Latinos (P=0.007 and 0.05, respectively).
|
20067482 |
2010 |
|
Squamous cell carcinoma
|
0.200 |
Biomarker
|
disease |
RGD |
Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2.
|
17985342 |
2008 |
|
Malignant Squamous Cell Neoplasm
|
0.200 |
Biomarker
|
disease |
RGD |
Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2.
|
17985342 |
2008 |
|
Myocardial Infarction
|
0.060 |
Biomarker
|
disease |
BEFREE |
Genetic variation in the genes ALOX5 (arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) in Caucasian and African American populations.
|
30678701 |
2019 |
|
Myocardial Infarction
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In FLAP, two SNPs were negatively associated with incident MI (rs9551963 & rs17222842) while one SNP (rs2247570) located in LTA4-H, was associated with higher risk of MI when comparing subjects with two copies of the variant allele to homozygotes for the wild type.
|
27893808 |
2016 |
|
Myocardial Infarction
|
0.060 |
Biomarker
|
disease |
BEFREE |
Although there was limited inter-study concordance of important loci, two gene variants in the leukotriene pathway (ALOX5AP and LTA4) have emerged as susceptibility factors for myocardial infarction (MI).
|
16987874 |
2006 |
|
Myocardial Infarction
|
0.060 |
Biomarker
|
disease |
BEFREE |
Here we show that a haplotype (HapK) spanning the LTA4H gene encoding leukotriene A4 hydrolase, a protein in the same biochemical pathway as ALOX5AP, confers modest risk of myocardial infarction in an Icelandic cohort.
|
16282974 |
2006 |