|
Adenocarcinoma
|
0.200 |
Biomarker
|
group |
RGD |
Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.
|
12865451 |
2003 |
|
Amino acids measurement
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
|
27005778 |
2016 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Human AAA wall tissue converts arachidonic acid and the unstable epoxide LTA(4) into significant amounts of cysteinyl-leukotrienes and to a lesser extent LTB(4).
|
21078989 |
2010 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
The authors sought to develop combined positron emission tomography (PET) dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to quantify plaque inflammation, permeability, and burden to evaluate the efficacy of a leukotriene A4 hydrolase (LTA4H) inhibitor in a rabbit model of atherosclerosis.
|
29413439 |
2018 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recently, leukotriene-based inflammation has also been shown to play an important role in atherosclerosis: ALOX5AP and LTA4H, both genes in the leukotriene biosynthesis pathway, have individually been shown to be associated with various cardiovascular disease (CVD) phenotypes.
|
19130089 |
2009 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis.
|
25721704 |
2015 |
|
Asthma
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that LTA4H A-9188>G, TNFα G-308>A and IL-4Rα A1727>G polymorphisms were significantly associated with the development of difficult asthma in paediatric patients (p<0.001, p = 0.019 and p = 0.037, respectively).
|
23573270 |
2013 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
RGD |
The expression of 5-LO and LTA4-H mRNA, and 5-LO protein levels were increased in lung tissue and cerebral cortex in asthma rats.
|
15715933 |
2005 |
|
Asthma
|
0.280 |
AlteredExpression
|
disease |
BEFREE |
LPS induced significant expression of ANXA1 and LTA4H in asthmatics when compared to COPD patients and healthy subjects.
|
25634111 |
2014 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
These data suggest that polymorphisms spanning ALOX5AP, LTA4H and the LTB4R locus are not major determinants of baseline lung function in smokers, but provide tentative evidence for LTA4H rs1978331C (intron 11) in determining baseline FEV1 and FEV1/FVC ratio in Caucasian Smokers in addition to our previously identified role in asthma susceptibility.
|
22206291 |
2011 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
ALOX5AP and LTA4H are associated with asthma susceptibility, suggesting a role for LTB4 in disease.
|
23167751 |
2012 |
|
Asthma
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
To assess the contribution of LTA4H and ALOX5AP polymorphism to asthma and allergy susceptibility.
|
18547289 |
2008 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
This region harbours a number of candidate genes for asthma and atopy, including stem cell factor (SCF), leukotriene A4 hydrolase (LTA4H), thyroid receptor 2 (TR2), and signal transducer and activator of transcription 6 (STAT6).
|
11069563 |
2000 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
BEFREE |
Leukotriene A4 Hydrolase Activation and Leukotriene B4 Production by Eosinophils in Severe Asthma.
|
30352167 |
2019 |
|
Asthma
|
0.280 |
Biomarker
|
disease |
LHGDN |
Single point analyses identified association (P < 0.05) between SNPs SG13S114, SG13S89, SG13S41 (ALOX5AP), rs1978331 (LTA4H) and asthma and/or related phenotypes.
|
18547289 |
2008 |
|
Asthma
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs within LTA4H (rs17525488 and rs2540493) were protective for asthma in Latinos (P=0.007 and 0.05, respectively).
|
20067482 |
2010 |
|
Atherogenesis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.
|
16698924 |
2006 |
|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
The authors sought to develop combined positron emission tomography (PET) dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to quantify plaque inflammation, permeability, and burden to evaluate the efficacy of a leukotriene A4 hydrolase (LTA4H) inhibitor in a rabbit model of atherosclerosis.
|
29413439 |
2018 |
|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
CTD_human |
The abundant expression of LTA4H and correlation with plaque instability identify LTA4H as a potential target for pharmacological intervention in treatment of human atherosclerosis.
|
16698924 |
2006 |
|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
Recently, leukotriene-based inflammation has also been shown to play an important role in atherosclerosis: ALOX5AP and LTA4H, both genes in the leukotriene biosynthesis pathway, have individually been shown to be associated with various cardiovascular disease (CVD) phenotypes.
|
19130089 |
2009 |
|
Atherosclerosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
The eicosanoid genes ALOX5, ALOX5AP and LTA4H have been implicated in atherosclerosis.
|
25721704 |
2015 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Leukotriene A4 hydrolase (LTA<sub>4</sub>H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene which may play an important role in chronic inflammation associated carcinogenesis.
|
28065501 |
2017 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
To assess the role of the leukotriene pathway in CVD pathogenesis, we performed genetic association studies of ALOX5AP and LTA4H in a family based study of early onset coronary artery disease (EOCAD) (GENECARD, 1,101 families) and in a non-familial dataset of EOCAD (CATHGEN, 656 cases and 405 controls).
|
19130089 |
2009 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The recent finding that genetic variants in 5-lipoxygenase activating protein and leukotriene A4 hydrolase may confer an increased risk of ischemic stroke has implicated the leukotriene family as potential mediators of cardiovascular disease.
|
18323512 |
2008 |
|
Cerebrovascular accident
|
0.020 |
Biomarker
|
group |
BEFREE |
Genetic variation in the genes ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) and stroke in Icelandic and Scottish populations.
|
18318662 |
2008 |