LTA4H, leukotriene A4 hydrolase, 4048

N. diseases: 63; N. variants: 11
Disease: Ischemic stroke ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.020 GeneticVariation disease BEFREE In combined analysis of multiple genes and loci, individuals with ALOX5AP rs12429692 T allele, ALOX5 rs2029253 A allele, and LTA4H rs6538697 C allele suggested a significantly increased susceptibility to IS (adjusted OR, 1.70; 95% CI, 1.07-2.69; P=0.024). 23079278 2012
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.020 Biomarker disease BEFREE The recent finding that genetic variants in 5-lipoxygenase activating protein and leukotriene A4 hydrolase may confer an increased risk of ischemic stroke has implicated the leukotriene family as potential mediators of cardiovascular disease. 18323512 2008