LTA, lymphotoxin alpha, 4049

N. diseases: 353; N. variants: 26
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.500 SusceptibilityMutation disease CLINVAR
CUI: C1835223
Disease: PSORIATIC ARTHRITIS, SUSCEPTIBILITY TO (finding)
PSORIATIC ARTHRITIS, SUSCEPTIBILITY TO (finding) 		0.100 SusceptibilityMutation disease CLINVAR
CUI: C2750103
Disease: LEPROSY, EARLY-ONSET, SUSCEPTIBILITY TO
LEPROSY, EARLY-ONSET, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0018129
Disease: Graft Rejection
Graft Rejection 		0.200 Therapeutic phenotype RGD Anti-tumor necrosis factor antibody enhances allograft survival in rats. 2338821 1990
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.200 GeneticVariation disease BEFREE This study suggests an association between the 10.5 kb TNF-beta allele and IDDM, and demonstrates an association between monokine responses and TNF-beta genotypes.(ABSTRACT TRUNCATED AT 400 WORDS) 1996407 1991
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.200 GeneticVariation disease BEFREE Tumour necrosis factor-beta polymorphism is unlikely to determine susceptibility to type 1 (insulin-dependent) diabetes mellitus. 1682200 1991
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.010 GeneticVariation disease BEFREE No deviation was found in the PBC collective (0.7) for the TNFB*2 distribution when compared with the control (0.67). 1684248 1991
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 GeneticVariation disease BEFREE In the TNF-beta gene, DNA methylation is decreased in several examples of acute or chronic myeloid leukemias in comparison to normal human granulocytes or monocytes, whose DNA is almost completely methylated between nucleotides 700 and 900. 2062856 1991
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.040 GeneticVariation disease BEFREE Tumor necrosis factor beta gene polymorphisms in Graves' disease. 1346144 1992
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.030 GeneticVariation disease BEFREE To address the possibility that a non-human leukocyte antigen (HLA) gene closely linked to the HLA-B gene, such as tumor necrosis factor (TNF)-alpha, TNF-beta, or ECl (the locus that determines the susceptibility to alloreactive natural killer [NK] cells), is involved in the susceptibility to Behçet's disease, NcoI and EcoRI restriction fragment length polymorphisms in the TNF-beta gene and the susceptibility to lysis by alloreactive NK cells were investigated in Behçet's patients. 1356945 1992
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.020 Biomarker disease BEFREE We investigated by Northern blotting the gene expressions of the pyrogenic and inflammation-associated cytokines IL-1 alpha, IL-1 beta, TNF-alpha, TNF-beta (lymphotoxin) and IL-6 in 14 HD lymph nodes and studied their relation to systemic symptoms (B symptoms). 1358770 1992
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.200 Biomarker disease BEFREE Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. 8093442 1993
CUI: C0018129
Disease: Graft Rejection
Graft Rejection 		0.200 Biomarker phenotype RGD Induction of TNF alpha and TNF beta gene expression in rat cardiac transplants during allograft rejection. 8356596 1993
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.200 Biomarker disease BEFREE Therefore, the whole haplotype A1, Cw7, B8, TNFB*1, C4A DE, DR3, DQ2 is increased in patients and it cannot be determined which of the genes carried by this haplotype is responsible for the susceptibility to SLE. 8436420 1993
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.080 GeneticVariation group BEFREE Since TNF may be involved in the pathogenesis of autoimmune disease the purpose of the present study was to investigate TNF beta gene polymorphism in two types of immune complex mediated glomerulonephritis, IgA nephropathy (IgAN) and idiopathic membranous glomerulonephritis (IMN) and to compare them with IDDM and healthy controls. 8222374 1993
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE The genotypic frequencies of tumor necrosis factor-beta and of heat shock protein 70, located within the HLA region on chromosome 6, in CF patients with diabetes were not different from those in patients with insulin-dependent diabetes mellitus, while non-diabetic CF patients and normal subjects shared other patterns. 8097419 1993
CUI: C0011847
Disease: Diabetes
Diabetes 		0.060 Biomarker disease BEFREE Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. 7682590 1993
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 Biomarker group BEFREE The genotypic frequencies of tumor necrosis factor-beta and of heat shock protein 70, located within the HLA region on chromosome 6, in CF patients with diabetes were not different from those in patients with insulin-dependent diabetes mellitus, while non-diabetic CF patients and normal subjects shared other patterns. 8097419 1993
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.060 Biomarker group BEFREE Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice. 7682590 1993
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.050 GeneticVariation disease BEFREE To clarify the molecular relationship between HLA loci and ulcerative colitis (UC) in Japanese patients, we performed HLA-DP genotyping by the PCR-RFLP method and studied tumor necrosis factor beta-chain genetic polymorphism by Southern hybridization, in addition to conventional serologic typing. 8096500 1993
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.010 GeneticVariation disease BEFREE These results demonstrate an association of TNF beta gene polymorphism with IMN and IgAN and confirm the associations found in IDDM. 8222374 1993
CUI: C0086445
Disease: Idiopathic Membranous Glomerulonephritis
Idiopathic Membranous Glomerulonephritis 		0.010 GeneticVariation disease BEFREE These results demonstrate an association of TNF beta gene polymorphism with IMN and IgAN and confirm the associations found in IDDM. 8222374 1993
CUI: C1328252
Disease: Mucocutaneous leishmaniasis
Mucocutaneous leishmaniasis 		0.010 AlteredExpression disease BEFREE The message for interferon-gamma (IFN-gamma), tumour necrosis factor-beta (TNF-beta), and IL-8 was expressed in the three clinical forms of ACL. 8443970 1993
CUI: C3495436
Disease: American cutaneous leishmaniasis
American cutaneous leishmaniasis 		0.010 AlteredExpression disease BEFREE The message for interferon-gamma (IFN-gamma), tumour necrosis factor-beta (TNF-beta), and IL-8 was expressed in the three clinical forms of ACL. 8443970 1993
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.200 Biomarker disease BEFREE The segregation of these alleles has been associated with levels of TNF alpha or TNF beta production in systemic lupus erythematosis (SLE), insulin-dependent diabetes mellitus (IDDM) and in healthy control individuals. 9098456 1994