LTA, lymphotoxin alpha, 4049

N. diseases: 353; N. variants: 26
Disease: Sarcoidosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease BEFREE Our meta-analysis demonstrates that the TNF-α -308 A/G and LT-α +252 A/G polymorphisms are associated with susceptibility to sarcoidosis in an European population. 24197700 2014
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease BEFREE This meta-analysis extended previous findings on the association between the TNF-α and TNF-β genetic polymorphisms and sarcoidosis, by showing that the TNF-β gene A252G polymorphism might be a potential risk factor for the development of sarcoidosis. 24244632 2013
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease BEFREE The significant differences in the distribution of TNFB*1 allele between the sarcoidosis an the control group was also noted (OR = 1,607, C.I. 21319595 2010
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease BEFREE These results confirm that variation in the LTA/TNF gene cluster modifies a major skin manifestation of sarcoidosis and may explain the higher rate of erythema nodosum in females with sarcoidosis. 19225544 2009
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease BEFREE Five potentially functional promoter polymorphisms in the TNFA gene and a LTA_NcoI polymorphism (+252 position) of the LTA gene were genotyped in a clinically well-defined cohort of North-Indian patients with sarcoidosis (n = 96) and their regional controls (n = 155). 18062795 2008
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease LHGDN Association of tumour necrosis factor-alpha, lymphotoxin-alpha and HLA-DRB1 gene polymorphisms with Löfgren's syndrome in Czech patients with sarcoidosis. 15713215 2005
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 Biomarker disease BEFREE In order to investigate whether polymorphisms of nearby pro-inflammatory genes located within the MHC class III region may also contribute to susceptibility to sarcoidosis or to its clinical manifestation, tumour necrosis factor-alpha (TNF-alpha) and lymphotoxin-alpha (LT-alpha) genes were chosen for analysis in a case-control association study. 15713215 2005
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease BEFREE However, our study identified the allele TNFB*1, detected by the presence of a NCO: I restriction site, as a marker of prolonged clinical course, with the resolution of sarcoidosis being defined as the disappearance of all clinical symptoms, physical signs of active lesions, abnormal chest radiograph findings, and abnormal results of pulmonary function and biochemical tests. 11243953 2001
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 GeneticVariation disease BEFREE We determined the TNFA and TNFB polymorphisms of 44 patients with sarcoidosis and found the following allele frequencies: 0.80, 0.20, 0.38 and 0.62 for TNFA1, TNFA2, TNFB1 and TNFB2, respectively. 10547277 1999
CUI: C0036202
Disease: Sarcoidosis
Sarcoidosis 		0.090 Biomarker disease BEFREE We screened the TNFA, TNFB, HSP70-1 and Hum70t genes around the class III region, as well as the HLA-DMA and -DMB genes in the class II region, for genetic polymorphism in sarcoidosis. 9349405 1997