MIRLET7B, microRNA let-7b, 406884

N. diseases: 186; N. variants: 1
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE Let-7b-5p was contrarily down-regulated in BC tissue. 31568692 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 Biomarker disease BEFREE Moreover, we previously reported an association between DRC levels and the expression of the microRNA (miRNA) let-7b in BC patients. 31191653 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE Compared with adjacent normal tissues, HOST2 expression was higher but let-7b expression lower in breast cancer tissues. 29236319 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE These findings support targeting active stromal fibroblasts through restoration of let-7b/IL-8 expression as a therapeutic option for breast carcinomas. 29707149 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE A significant difference in Let-7b expression was found in BC patients with high DRC versus the remaining groups (p < 0.001). 27271599 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 AlteredExpression disease BEFREE Furthermore, let-7b was found downregulated in the most aggressive forms of breast cancer determined by clinicopathological parameters. 25682900 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 Biomarker disease BEFREE Transfection of breast cancer cells with synthetic microRNAs and their inhibitors showed that let-7b and miR-202 did not affect the protein expression of MAGE-A1. 24983365 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.080 Biomarker disease BEFREE Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue. 22294324 2012