|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Structural changes of globular proteins and their resultant amyloid aggregation have been associated with various human diseases, such as lysozyme amyloidosis and light-chain amyloidosis.
|
31439662 |
2019 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lysozyme is an amyloidogenic protein which is often used as a model protein for studying amyloidosis.
|
31276926 |
2019 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
An In Vitro elucidation of the antiaggregatory potential of Diosminover thermally induced unfolding of hen egg white lysozyme; A preventive quest for lysozyme amyloidosis.
|
30794897 |
2019 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As there is no radical therapy for lysozyme amyloidosis, patients were given symptomatic treatment such as antihypertensive drugs and antibiotics.
|
31395023 |
2019 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Formation of poly/peptide amyloid aggregates is also associated with the widely spread diseases, so called amyloidosis, which include Alzheimer's disease, diabetes mellitus and lysozyme amyloidosis.
|
29550545 |
2018 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influence of the ionic liquid 1-butyl-3-methylimidazolium bromide on amyloid fibrillogenesis in lysozyme: Evidence from photophysical and imaging studies.
|
29080820 |
2018 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We present here a modulating effect on lysozyme derived Amyloid β fibrils by aqueous magnetic fluid.
|
30392065 |
2018 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that binding of resveratrol to HuL could protect against the formation of pathogenic, cytotoxic aggregates formed in amyloidogenic disorders, such as systemic amyloidosis; thus suggesting its potential as a plausible therapeutic agent against lysozyme amyloidosis.
|
29105927 |
2018 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hereditary Lysozyme Amyloidosis Variant p.Leu102Ser Associates with Unique Phenotype.
|
28049649 |
2017 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lysozyme amyloidosis (ALys) is a disease of the gastrointestinal tract, liver and kidneys, which is caused by the accumulation of insoluble fibrils of lysozyme in the tissues of above organs.
|
28827166 |
2017 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hereditary lysozyme amyloidosis with sicca syndrome, digestive, arterial, and tracheobronchial involvement: case-based review.
|
28963698 |
2017 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibrillation of lysozyme/insulin/amyloid beta in extracellular space, aggregation of mutant huntingtin protein inside model neuronal cell, and cytotoxic effect of fibrils are investigated in the presence of these sugar nanoparticles.
|
28272865 |
2017 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are clear indications that SAP may play an important role in lysozyme amyloidosis, which requires further elucidation.
|
27428539 |
2016 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report and describe symptoms and gastrointestinal tract involvement in a new family with hereditary lysozyme amyloidosis.
|
25217048 |
2014 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lysozyme, which is the amyloidogenic precursor protein in ALys, is a ubiquitous bacteriolytic enzyme synthesized by hepatocytes, polymorphs and macrophages.
|
21988333 |
2012 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have created a Drosophila model of lysozyme amyloidosis to investigate the in vivo behavior of disease-associated variants.
|
21965601 |
2012 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We describe a new mutation in exon 2 of the lysozyme gene associated with amyloidosis (ALys) in a 61-year-old woman with a 7-year history of non-bloody, watery diarrhea, and weight loss.
|
22978355 |
2012 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Interestingly, this form of ALys amyloidosis is also characterized by the occurrence of proteolytic fragments of lysozyme in the amyloid deposits.
|
16329101 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ALys amyloidosis caused by compound heterozygosity in exon 2 (Thr70Asn) and exon 4 (Trp112Arg) of the lysozyme gene.
|
16329101 |
2006 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme.
|
16126226 |
2005 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One of the 20 or so human amyloid diseases is associated with the deposition in vital organs of full-length mutational variants of the antibacterial protein lysozyme.
|
15713462 |
2005 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Simulations of human lysozyme: probing the conformations triggering amyloidosis.
|
12668424 |
2003 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report here a new family with hereditary lysozyme amyloidosis who presented predominantly with gastrointestinal involvement.
|
12360495 |
2002 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The phenotype, reported for the first time in this extended kindred, contrasts with that of an apparently unrelated family carrying the same mutation who presented with spontaneous hepatic haemorrhage and rupture, and with the manifestations in a family with the lysozyme Ile56Thr variant who presented with dermal petechiae before proceeding to fatal visceral amyloidosis.
|
10534505 |
1999 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effects of 4 proteolytic enzymes, alpha-chymotrypsin, bromeline, collagenase, and lysozyme on amyloid tissue sections from a patient with familial amyloidotic polyneuropathy (FAP) were evaluated.
|
2837542 |
1988 |