Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the expression of miR-21, miR-221, miR-143, and miR-106a in patients' osteosarcoma samples, and to explore the correlation between these microRNAs (miRNAs) and the clinical stage of osteosarcoma.
|
31084400 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition miR-143-3p inhibited OS cell proliferation and metastasis while promoting apoptosis.
|
29330462 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of the present study indicated that miR-143 could be a potential target for treating OS.
|
28734729 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.
|
28977896 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To our knowledge, it was the first time to target Bcl-2 directly to explore the underlying mechanism by which miR-143 performed its role to induce apoptosis in tumor cells, thus improving osteosarcoma progression.
|
27133034 |
2016 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the biological role and mechanism of miR-143 in the metastasis of human osteosarcoma cells.
|
26817521 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MiR-143 showed down-regulation in osteosarcoma tissues.
|
26823739 |
2015 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of miR-143 expression was observed in osteosarcomas, which correlated with shorter survival of patients with osteosarcomas underlying chemotherapy.
|
25576341 |
2015 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that TGF-β1 up-regulates versican expression by suppressing miR-143, and this pathway is important for osteosarcoma cell migration and invasion.
|
25562163 |
2014 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The delivery efficiency of exosome-formed miR-143 was less than that achieved with lipofection, but the migratory potential of osteosarcoma cells was similarly inhibited after both strategies.
|
24525123 |
2014 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data suggest that miR-143 inhibits EGFR signaling through its downstream ERK/MAPK signaling cascades to control MMP9 expression in OS.
|
25227664 |
2014 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, propofol may have antitumor potential in osteosarcoma, which is partly due to the downregulation of MMP-13 expression by miR-143.
|
24762226 |
2013 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed that circulating levels of miR-21 were significantly higher in osteosarcoma patients than controls, while miR-199a-3p and miR-143 were decreased in osteosarcoma patients.
|
23269581 |
2013 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These effects were associated with decreased expression of Notch-1 and its downstream genes, such as vascular endothelial growth factor and matrix metalloproteinases, as well as increased expression of a panel of tumor-suppressive microRNAs (miRNAs), including miR-34a, miR-143, miR-145 and miR-200b/c that are typically lost in osteosarcoma.
|
23430952 |
2013 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data indicated that the downregulation of miR-143 correlates with the lung metastasis of human osteosarcoma cells by promoting cellular invasion, probably via MMP-13 upregulation, suggesting that miRNA could be used to develop new molecular targets for osteosarcoma metastasis.
|
21427707 |
2011 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, our data identify the important roles of miR-143 in osteosarcoma pathogenesis and indicate its potential application in cancer therapy.
|
20878132 |
2010 |