MIR146A, microRNA 146a, 406938

N. diseases: 505; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 GeneticVariation disease LHGDN A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. 18711148 2008
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.060 AlteredExpression group BEFREE These findings implicate miR-146a/b as a negative regulator of constitutive NF-kappaB activity in a breast cancer setting and suggest that modulating miR-146a/b levels has therapeutic potential to suppress breast cancer metastases. 18504431 2008
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.050 GeneticVariation disease LHGDN Taken together, our data suggest that breast/ovarian cancer patients with variant C allele miR-146a may have high levels of mature miR-146 and that these variants predispose them to an earlier age of onset of familial breast and ovarian cancers. 18660546 2008
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.040 GeneticVariation disease LHGDN Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. 18474871 2008
CUI: C1328504
Disease: Hormone refractory prostate cancer
Hormone refractory prostate cancer 		0.030 Biomarker disease BEFREE Loss of mir-146a function in hormone-refractory prostate cancer. 18174313 2008
CUI: C0677776
Disease: Hereditary Breast and Ovarian Cancer Syndrome
Hereditary Breast and Ovarian Cancer Syndrome 		0.010 GeneticVariation disease BEFREE A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis. 18660546 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 AlteredExpression disease BEFREE These results further support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis. 19190326 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 AlteredExpression disease BEFREE These results further support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis. 19190326 2009
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.350 AlteredExpression group LHGDN Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis. 19190326 2009
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.100 GeneticVariation disease BEFREE We conducted a three-stage case-control study of CHD in Chinese to test our hypothesis by genotyping miR-196a2 rs11614913 and three other pre-miRNA SNPs (miR-146a rs2910164, miR-149 rs2292832, and miR-499 rs3746444) in 1,324 CHD cases and 1,783 non-CHD controls. 19514064 2009
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 AlteredExpression disease BEFREE Further analysis showed that underexpression of miR-146a negatively correlated with clinical disease activity and with interferon (IFN) scores in patients with SLE. 19333922 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype LHGDN These results further support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis. 19190326 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype BEFREE These results further support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis. 19190326 2009
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 AlteredExpression phenotype BEFREE Concurrently, BRMS1 increased expression of metastasis suppressing miRNA (miR-146a, -146b and -335). 19585508 2009
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE TaqMan analysis of paired tumor/normal samples revealed 1.5- to 2.6-fold overexpression of polymorphic miR-146a* in 7 of 8 tumors compared with the unaffected part of the same gland. 19164563 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.100 AlteredExpression disease BEFREE In grades II and III OA cartilage, the expression of miR-146a and COL2A1 was decreased, whereas the expression of matrix metalloproteinase 13 (MMP-13) was elevated in grade II OA cartilage. 19333945 2009
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.040 Biomarker disease BEFREE Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. 19164563 2009
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.040 Biomarker disease BEFREE Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. 19164563 2009
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris 		0.030 GeneticVariation disease BEFREE Underexpression of miR-146a contributes to alterations in the type I IFN pathway in lupus patients by targeting the key signaling proteins. 19333922 2009
CUI: C0024138
Disease: Lupus Erythematosus, Discoid
Lupus Erythematosus, Discoid 		0.030 GeneticVariation disease BEFREE Underexpression of miR-146a contributes to alterations in the type I IFN pathway in lupus patients by targeting the key signaling proteins. 19333922 2009
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus 		0.030 GeneticVariation disease BEFREE Underexpression of miR-146a contributes to alterations in the type I IFN pathway in lupus patients by targeting the key signaling proteins. 19333922 2009
CUI: C0007115
Disease: Malignant neoplasm of thyroid
Malignant neoplasm of thyroid 		0.020 Biomarker disease BEFREE Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer. 19164563 2009
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.010 Biomarker disease BEFREE The expression values of 9 among the 32 microRNAs (miR-151-3p, miR-34a, miR-29c, miR-29b, miR-155, miR-148a, miR-146a, miR-146b5p, and miR-640) were correlated with gene expression data from the same samples to assess their biologic impact on CLL. 19717645 2009
CUI: C4290046
Disease: trachomatis
trachomatis 		0.010 GeneticVariation disease BEFREE We investigated whether the SNPs miR-146a G>C (rs2910164), NLRP3 C>T (rs4925663) and G>A (rs12065526) are associated with the susceptibility to and severity of C. trachomatis infection. 20011700 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker disease CTD_human Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. 20099276 2010