Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The miR-146a expression, which regulates both of IL-1β and IL-6 expression, was decreased after the BL-administration in both of the healthy and in CRC-mice.
|
30862187 |
2019 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.
|
30980673 |
2019 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the data based on race revealed that rs2910164 (miR-146a) polymorphism may decrease the risk of CRC among Europeans, in a co dominant model [OR = 0.81, 95% CI 0.66-0.99, p = 0.04], but not among Asians.
|
30447914 |
2018 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the association of hsa-mir-149 rs2292832 C/T, hsa-mir-146a rs2910164 G/C and hsa-mir-196a2 rs11614913 C/T and explored their roles in clinicopathological features of CRC progression in an Eastern Tunisian cohort.
|
29715515 |
2018 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study provides evidence that miR-146a rs2910164 polymorphism may play an important role in susceptibility to CRC in Chinese male population.
|
29578157 |
2018 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, miR-146a-5p represents potential targets for CRC diagnosis and therapy.
|
28186967 |
2017 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we identified a variety of miRNAs (miRNA-let-7, miR-34b/c, miR-146a, miR-603 and miR-149) gene polymorphisms that are associated with susceptibility to CRC.
|
28521462 |
2017 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also found CRC risk was not associated with mir-146a and mir-149 polymorphisms in population subgroup analysis.
|
26208586 |
2016 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the association of six polymorphisms (miR-608 rs4919510, miR-499a rs3746444, miR-146a rs2910164, pre-miR-143 rs41291957, pre-miR-124-1 rs531564 and pre-miR-26a-1 rs7372209) with colorectal cancer (CRC) risk, therapeutic response and survival remains unclear.
|
27713147 |
2016 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also investigated the association between miR-146a polymorphism and miR-146a, NUMB expression or migratory response in CRC cell lines.
|
27824903 |
2016 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the SNPs rs2292832 in miR-149 and rs895819 in pre-miR-27a were associated with CRC susceptibility, whereas rs11614913, rs2910164, and rs3746444 in miR-196a-2, miR-146a, and miR-499, respectively, were not.
|
27706637 |
2016 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the rs2910164 polymorphism in pre-miRNA, miR-146a may be associated with the risk of CRC.
|
25519012 |
2015 |
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate an association between miR-146a dysregulation and colorectal cancer, and suggest that miR-146a may play a role in colorectal carcinogenesis.
|
24740563 |
2014 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our current meta-analysis demonstrates that miR-196a2 rs11614913 most likely contributes to decreased risk of CRC, whereas miR-146a rs2910164 may not be associated with the susceptibility to CRC.
|
24399071 |
2014 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed a tendency for miR-146a C allele to be associated with lower risk of CRC when compared to G allele, however, the difference did not reach the adjusted P-value (odds ratio (OR) = 0.68, 95% confidence interval (CI) 0.49-0.95, P = 0.025).
|
25103961 |
2014 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MiR-146a (rs2910164 G > C) polymorphism is associated with CRC susceptibility and histological differentiation in Chinese Han population.
|
24136745 |
2014 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
miR-146a G/C genetic polymorphism was not related to the susceptibility to CRC.
|
25283877 |
2014 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that the miR-146a polymorphism rs2910164 might significantly increase the susceptibility of digestive tumors, in particular for esophageal cancer and colorectal cancers.
|
24247819 |
2014 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that miR-146a rs2910164 may contribute to the susceptibility to CRC in a Chinese population.
|
23306950 |
2013 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current study provides evidence that the miR-146a rs2690164 polymorphism, as the dominant model of the G allele, is associated with the susceptibility and prognosis of CRC.
|
23898084 |
2013 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the distribution of sequence variants of miR-146a, miR-196a2, miR-499 and miR-149 in colorectal cancer (CRC) and their effect on miRNA expression.Each variant was identified with HRM.
|
22989523 |
2013 |
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer.
|
22719192 |
2012 |