MIR146A, microRNA 146a, 406938

N. diseases: 505; N. variants: 3
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 Biomarker disease BEFREE Loss of function and overexpression studies were performed via transfection with miR-146a mimic/inhibitor in cultured BV-2 cell lines and intrahippocampal injection of miR-146a agomir/antagomir before surgery/anesthesia to identify the role of miR-146a in neuroinflammation and cognitive impairment. 30685530 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 Biomarker disease BEFREE Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model. 31707205 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 Biomarker disease BEFREE An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells. 30240403 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 GeneticVariation disease BEFREE A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients. 24586483 2014