|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, it is suggested that miR-187 functions as a tumor suppressor in GC, and is important in the development and progression of GC.
|
30112051 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased expression level of miR-187 was associated with adverse clinical features including tumor size, lymph metastasis and TNM stage, and decreased overall survival and disease-free survival of GC patients.
|
28098868 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results of the present study demonstrated that miR‑187 acted as a tumor suppressor in HCC progression via direct targeting of IGF‑1R. miR‑187 may therefore exhibit the potential to act as a novel and therapeutic target for HCC treatment in the future.
|
28627639 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, miR-187 promoted tumor growth in vivo, and significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells.
|
27864146 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, targeting FGF9 was required for miR-187 exerting its tumor suppressive roles in cervical cancer cells.
|
28849071 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MiRNA-187 has been reported in nasopharyngeal, renal, pancreatic, prostate, and esophageal cancer, and acts as a tumor suppressor or oncogene.
|
28968959 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
miR-187 inhibits tumor growth and invasion by directly targeting MAPK12 in osteosarcoma.
|
28810556 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor.
|
27542258 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, miR-187 expression in tumor cells could perturb cell cycle which supported its possible role as tumor suppressor.
|
26642897 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNA-187 inhibits tumor growth and invasion by directly targeting CD276 in colorectal cancer.
|
27329595 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a murine xenograft model established with subcutaneous injection of Jurkat cells, bortezomib particularly retarded the growth of miR187-overexpressing tumors, consistent with the downregulation of miR187, Ki67 and MYC expression.
|
24104394 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
During the later stages, however, continued increased levels of miR-187 inhibits the Dab2-dependent EMT that is associated with tumor invasiveness, which is presumed to be the reason why cancers with high miR-187 levels were associated with better survivals.
|
21725366 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High expression of miR-212 and miR-675 and low expression of miR-148a, miR-187, and let-7g predicted short OS independent of age, gender, calendar year of operation, KRAS mutation status, tumor stage, American Society of Anesthesiologists (ASA) score, localization (not miR-148a), and differentiation of tumor.
|
22851141 |
2012 |