|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significantly lower miR-145-5p and miR-203-3p expression levels were found in cases with Breslow thickness >1 mm, high Clark level, ulceration and mitotic rate ≥1/mm<sup>2</sup> Conclusion: Our findings point to miR-205-5p as potential biomarker of distant metastases and to miR-145-5p and miR-203-3p as markers of aggressiveness in melanoma.
|
31366492 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of long non-coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR-205-EGLN2 pathway.
|
30843652 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study reveals the genes C7, MMP3, KRT14, LOC642587, CASP7, S100A7 and miRNAs hsa-mir-205 and hsa-mir-203b as the key genomic features that may substantially contribute to the oncogenesis of melanoma.
|
31673075 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Then, miR-205 which had binding site with lncRNA CRNDE and CCL18 was involved in the next experiment, and it was down-regulated in melanoma that negatively correlated with lncRNA CRNDE expression.
|
30257602 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that the downregulation of miR-205 in primary melanomas is an intrinsic property that might contribute to distant metastasis.
|
30459436 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increase of miR-21 and miR-142, and decrease of miR-125b, miR-211, miR-101 and miR-513c in the melanomas were verified in both cohorts using qPCR, whereas the decrease of miR-205 observed with array analysis could not be confirmed using qPCR.
|
28614272 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among the top, miR-21-5p, let-7b-5p, let-7a-5p, miR-424-5p, miR-423-5p, miR-21-3p, miR-199b-5p, miR-182-5p, and miR-205-5p were differentially expressed between thin and thick melanomas.
|
28218741 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that miR-203 is a new prognostic factor in canine oral MMs and that miR-205 functions as a tumour suppressor by targeting erbb3 in both canine and human MM cells.
|
23638671 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Six microRNAs (miR-9, miR-145, miR-150, miR-155, miR-203, and miR-205) were evaluated using real-time PCR in 11 patients with metastatic melanoma and in 16 patients without melanoma.
|
23863473 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the intratumoral injection of miR-205BP/S3 exhibited a significant antitumor effect compared with the case of control miRNA or Pre-miR-205 in human melanoma cell-xenografted mice.
|
23629002 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In all, 20 miRNAs showed highly significant differential expression between benign naevi and either primary or metastatic melanomas, the majority being downregulated in melanoma, whereas only 2 miRNAs, namely miR-203 and miR-205, were differentially expressed between primary and metastatic melanomas.
|
22223089 |
2012 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low levels of melanoma cell miR-205 expression as quantified by ISH show worse outcome, supporting the role of miR-205 as a tumor suppressor miRNA.
|
22890556 |
2012 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enforced miR-205 expression in melanoma cells profoundly impairs cell motility and migration along with significantly decreased F-actin polymerization with only a modest reduction in cell proliferation.
|
22525428 |
2012 |