Collectively, the present study demonstrates a causative effect of miR-210 in the downregulation of TET1 and subsequent repression of BK<sub>Ca</sub> channel expression and function, providing a novel mechanistic insight into the regulation of BK<sub>Ca</sub> channel function and the molecular basis underlying the maladaptation of uterine vascular function in gestational hypoxia.
Together, the results demonstrate that miR-210 plays an important role in the downregulation of ten-eleven translocation methylcytosine dioxygenase 1 and repression of BK<sub>Ca</sub> channel function in uterine arteries, revealing a novel mechanism of epigenetic regulation in the maladaptation of uterine hemodynamics in gestational hypoxia and preeclampsia.