Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We concluded MiR-34a-5p suppressed tumorigenesis and progression of glioma and potentiated TMZ-induced cytotoxicity for glioma cells by targeting HMGA2, deepening our understanding on molecular basis of HMGA2 in glioma.
|
30851271 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reverse transcription‑quantitative polymerase chain reaction was used to analyze the expression of MMP‑9 and microRNA‑34a (miR‑34a) in the plasma of patients with glioma and healthy volunteers.
|
31115528 |
2019 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results demonstrated a novel role for miR‑34a, inducing glioma cell senescence, whereas miR‑34a modulation of SIRT1, inducing DNA damage, is crucial for miRNA replacement therapy in glioma treatment.
|
30592284 |
2019 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
QRT-PCR and western blot were used to measure the relative expression levels of circNFIX, miR-34a-5p and <i>NOTCH</i> and identify their correlation in glioma.
|
30072869 |
2018 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Long non-coding RNA antisense non-coding RNA in the INK4 locus (ANRIL) variants are associated with glioma and miR-34a is markedly downregulated in U251 glioma cells.
|
29057547 |
2018 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MiR-34a mimics was transfected into CD133 + glioma cell U251.
|
28859546 |
2017 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of miR-34a inhibited glioma cell proliferation, promoted cell cycle arrest in G1/S phase and cell apoptosis.
|
28721584 |
2017 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study investigated the function of miR‑34a in U87 human glioma cells by exogenously transfecting cells with an miR‑34a mimic.
|
27176117 |
2016 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, miR-34a overexpression significantly down-regulates the expression and distribution of tight junction-related proteins in glioma endothelial cells (GECs), paralleled by protein kinase Cε (PKCε) reduction.
|
25788289 |
2015 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MiR-34a expression was significantly reduced in human glioma A172 cells and glioma tissue, compared with normal glial cells and tissue samples.
|
24393844 |
2014 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Univariate and multivariate analysis revealed that miR-34a was an independent prognostic indicator for glioma.
|
23529798 |
2013 |
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The insensitivity of glioma to standard therapies combined with the hypothesis that glioma stem cells (GSCs) are responsible for this chemorefractory nature suggests that investigations exploring the function and mechanism of miR-34a in GSCs would be of value.
|
22568628 |
2012 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The new data show that miR-34a expression inhibits various malignancy endpoints in glioma stem cells.
|
20190569 |
2010 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of miR-34a in glioma cell lines and normal brains were detected using qRT-PCR.
|
20470934 |
2010 |
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Also, transient expression of miR-34a in glioblastoma cells strongly inhibited in vivo glioma xenograft growth.
|
19773441 |
2009 |