|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the mechanism that underlies miR-34a regulating proliferation, migration, invasion and autophagy in NB remains poorly understood.
|
30716314 |
2019 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> The expression level of miR-34a was decreased (<i>p</i> < .05) while the expression level of HNF4α was increased (<i>p</i> < .05) in paediatric neuroblastoma tissues.
|
31343368 |
2019 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We further found that (1) miR-34a binds the 3'UTR of ADRA2A, (2) the amount of repression is greater when the minor (risk) allele is present, (3) miR-34a in the IMR-32 adrenergic neuroblastoma cell line affects ADRA2A expression, (4) miR-34a and ADRA2A are expressed in tissues known to play a role in pain and stress, (5) following forced swim stress exposure, rat peripheral nerve tissue expression changes are consistent with miR-34a regulation of ADRA2A.
|
27805929 |
2017 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, proteome analysis has here identified early targets of miR-34a with relevance to NBL tumorigenesis.
|
24912852 |
2014 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate the first silica nanoparticle-based targeted delivery of a tumor suppressive, pro-apoptotic microRNA, miR-34a, to neuroblastoma tumors in a murine orthotopic xenograft model.
|
22662276 |
2012 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To better understand the biological pathways involved in miR-34a action, a parallel global protein and mRNA expression profiling on miR-34a treated neuroblastoma cells (IMR32) was performed using isotope-coded affinity tags (ICAT) and Affymetrix U133plus2 microarray, respectively.
|
21182263 |
2011 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of miR-34a is modulated in parallel with that of TAp73 during in vitro differentiation of neuroblastoma cells and cortical neurons.
|
22160687 |
2011 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Over expression of miR-34a in both NB1691luc and SK-N-ASluc neuroblastoma cell lines led to a significant decrease in cell number relative to premiR-negative control treated cells over a 72 hour period.
|
21266077 |
2011 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
More recently, the dysregulation of some miRNAs, including the miR-17-5p-92 cluster and miR-34a, has been implicated in the pathobiology of neuroblastoma.
|
19199973 |
2009 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Thus, mutations in the binding site are not an additional mechanism for the inactivation of miR-34a in NB.
|
19373781 |
2009 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma.
|
18504438 |
2008 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of miR-34a was also decreased in primary tumors (n = 54) with 1p36 deletion (P = 0.009), but no mutations were discovered in resequencing of the miR-34a locus in 30 neuroblastoma cell lines.
|
18505919 |
2008 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, adding to the increasing role of miRNAs in cancer, miR-34a may act as a suppressor of NB tumorgenesis.
|
17297439 |
2007 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin homolog deleted on chromosome 10-dependent activation of PI 3-kinase signaling. miR-34a acts as a suppressor of neuroblastoma tumorigenesis by targeting the mRNA encoding E2F3 and reducing E2F3 protein levels.
|
17894887 |
2007 |